公开(公告)号：US20110045028A1

公开(公告)日：2011-02-24

申请号：US12516536

申请日：2007-11-29

申请人： Satoshi Iinuma ,  Yoshie Iinuma ,  Tomohiro Yoshinari ,  Tsuneaki Tottori

发明人： Satoshi Iinuma ,  Yoshie Iinuma ,  Tomohiro Yoshinari ,  Tsuneaki Tottori

IPC分类号： A61K31/513 ,  A61K9/00 ,  A61P7/02 ,  A61P9/10

CPC分类号： A61K31/506 ,  A61K9/2018 ,  A61K9/2054

摘要： Disclosed is a sustained-release preparation which is prepared by shaping a granule comprising a blood coagulation factor Xa inhibitor and a mixture of at least two hydrophilic polymers. Also disclosed is a pharmaceutical composition comprising a combination of the sustained-release preparation and an immediate release preparation comprising a blood coagulation factor Xa inhibitor. It becomes possible to provide a controlled release preparation comprising a blood coagulation factor Xa inhibitor for the prevention or treatment of thrombosis, which can control the activity of blood coagulation factor Xa for a long term and is excellent in convenience and compliance. It is also becomes possible to provide a method for producing the controlled release preparation.

摘要翻译： 公开了一种缓释制剂，其通过使包含凝血因子Xa抑制剂和至少两种亲水性聚合物的混合物的颗粒成形而制备。 还公开了包含缓释制剂和包含凝血因子Xa抑制剂的速释制剂的组合的药物组合物。 可以提供一种控制释放制剂，其包含凝血因子Xa抑制剂，用于预防或治疗血栓形成，其可以长期控制凝血因子Xa的活性，并且方便性和顺应性优异。 也可以提供一种制备控释制剂的方法。