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1.发明授权公开(公告)号：US06903116B2
公开(公告)日：2005-06-07
申请号：US10339063
申请日：2003-01-09
IPC分类号： C07D405/06 , A61K31/445 , A61K31/40
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor.The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequenc in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译： 通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。 新型化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质产生的抑制剂，其抑制热休克因子（转录调节因子）的活性，从而进而抑制转录 在基因区域中具有用于转录调节RNA的热休克元件的结构基因的结构基因，从而抑制基因翻译成蛋白质，并导致抑制由该基因编码的RNA或蛋白质的产生。 它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。
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公开(公告)号：US06281229B1
公开(公告)日：2001-08-28
申请号：US09446286
申请日：2000-03-27
IPC分类号： A61K31445
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译： 通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质的产生的抑制剂，其中 抑制热休克因子的活性，转录调节因子，从而进一步抑制基因区域中具有热休克元件序列的结构基因的转录，用于转录调节成RNA，从而抑制基因转化为蛋白质， 并导致抑制由该基因编码的RNA或蛋白质的产生。 它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。
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公开(公告)号：US06613780B2
公开(公告)日：2003-09-02
申请号：US09939901
申请日：2001-08-27
IPC分类号： A61K31445
CPC分类号： C07D405/06
摘要： A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an inhibitor of inducing the production of a protein regulated by HSF, which inhibits the activity of a heat shock factor, a transcriptional regulatory factor, thereby in turn inhibiting transcription of a structural gene having a heat shock element sequence in the gene region for transcriptional regulation into RNA, and thus inhibiting translation of the gene into a protein, and resulting in inhibition of inducing production of RNA or protein encoded by the gene. It also provides a drug for treating or preventing cancer through thermotherapy and a drug for treating or preventing stress diseases such as depression.
摘要翻译： 通过控制由热休克因子诱导的蛋白质的表达来提供疾病治疗。新化合物苯并-1,3-二氧杂环戊烷提供HSF活性的抑制剂或诱导由HSF调节的蛋白质的产生的抑制剂，其中 抑制热休克因子的活性，转录调节因子，从而进一步抑制基因区域中具有热休克元件序列的结构基因的转录，用于转录调节成RNA，从而抑制基因转化为蛋白质， 并导致抑制由该基因编码的RNA或蛋白质的产生。 它还提供通过热疗治疗或预防癌症的药物和用于治疗或预防压力疾病如抑郁症的药物。
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公开(公告)号：US20100022604A1
公开(公告)日：2010-01-28
申请号：US12518450
申请日：2007-12-20
IPC分类号： A61K31/4245 , C07D271/06 , A61P17/14
CPC分类号： A61K31/4245 , A61K8/49 , A61Q7/00 , C07D413/04
摘要： Disclosed is a novel therapeutic agent which is useful for the prevention or treatment of alopecia. Specifically disclosed is a prophylactic or therapeutic agent for alopecia, which comprises 1-[2-((2S)-2-{5-[(3,4-dimethoxyphenoxy)methyl]-1,2,4-oxadiazol-3-yl}pyrrolidin-1-yl)-1,1-difluoro-2-oxoethyl]-3,3,5,5-tetramethylcyclohexanol as an active ingredient.
摘要翻译： 公开了一种可用于预防或治疗脱发的新型治疗剂。 具体公开的是脱发的预防或治疗剂，它包括1-〔2 - （（2S）-2- {5 - 〔（3,4-二甲氧基苯氧基）甲基〕-1,2,4-恶二唑-3-基 }吡咯烷-1-基）-1,1-二氟-2-氧代乙基] -3,3,5,5-四甲基环己醇作为活性成分。
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公开(公告)号：US20130323763A1
公开(公告)日：2013-12-05
申请号：US13984623
申请日：2012-02-10
IPC分类号： G01N33/68
CPC分类号： G01N33/6884 , G01N33/6893 , G01N2800/12 , G01N2800/50 , G01N2800/52
摘要： The present invention provides a useful examination method and diagnostic reagent, which are capable of diagnosing acute lung injury in clear distinction from chronic progressive interstitial pneumonia. Specifically, the present invention provides a method of determining whether or not a test subject is affected with acute lung injury, which comprises quantifying heat shock protein 47 in a biological sample derived from the test subject.
摘要翻译： 本发明提供了一种有用的检查方法和诊断试剂，其能够与慢性进行性间质性肺炎明确区别地诊断急性肺损伤。 具体地，本发明提供一种确定受试对象是否受到急性肺损伤的影响的方法，其包括定量来自受试者的生物样品中的热休克蛋白47。
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