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    Quinoline derivatives, their production and use
    1.
    发明授权
    Quinoline derivatives, their production and use 失效
    喹啉衍生物，其生产和使用

    公开(公告)号：US6087503A

    公开(公告)日：2000-07-11

    申请号：US152514

    申请日：1998-09-14

    申请人： Shuichi Furuya ,  Nobuo Choh ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Nobuo Choh ,  Satoshi Sasaki

    IPC分类号： C07D215/56

    CPC分类号： C07D215/56

    摘要： The present compounds are intermediates for the preparation of quinoline derivatives and compositions having gonadotropin-releasing hormone antagonistic activity useful as propylactics or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine or cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals, and as agents for promoting spawning in fish.

    摘要翻译： 本发明化合物是用于制备喹啉衍生物的中间体和具有促性腺激素释放激素拮抗活性的组合物，其用作预防或治疗若干激素依赖性疾病例如性激素依赖性癌症（例如前列腺癌， 子宫颈癌，乳腺癌，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前期综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）有效; 可用作男性或女性避孕药，作为排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用于调节畜牧业动物的发情周期，作为改善食用肉质量或促进动物生长的药剂，以及用于促进鱼类产卵的药剂。

    Thienopyridine compounds which have useful pharmaceutical activity
    2.
    发明授权
    Thienopyridine compounds which have useful pharmaceutical activity 失效
    具有有用药物活性的噻吩并吡啶化合物

    公开(公告)号：US5744479A

    公开(公告)日：1998-04-28

    申请号：US779608

    申请日：1997-01-07

    申请人： Shuichi Furuya ,  Nobuo Choh ,  Masataka Harada ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Nobuo Choh ,  Masataka Harada ,  Satoshi Sasaki

    IPC分类号： C07D495/04 ,  A61K31/33 ,  C07D419/02

    CPC分类号： C07D495/04

    摘要： The present thienopyrimidine derivatives and compositions having gonadotropin-releasing hormone antagonistic activity are useful as propylactics or therapeutic agents for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals; and as agents for promoting spawning in fish.

    摘要翻译： 本发明的噻吩并嘧啶衍生物和具有促性腺激素释放激素拮抗活性的组合物可用作预防或治疗若干激素依赖性疾病的丙型或治疗剂，例如性激素依赖性癌症（例如前列腺癌，子宫颈癌，乳腺癌 ，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前期综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）有效; 可用作男性或女性避孕药，作为排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用于调节畜牧业动物的发情周期，作为提高食用肉质量或促进动物生长的药剂; 并作为促进鱼类产卵的代理商。

    Quinoline derivatives, their production and use
    3.
    发明授权
    Quinoline derivatives, their production and use 失效
    喹啉衍生物，其生产和使用

    公开(公告)号：US5807869A

    公开(公告)日：1998-09-15

    申请号：US779609

    申请日：1997-01-07

    申请人： Shuichi Furuya ,  Nobuo Choh ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Nobuo Choh ,  Satoshi Sasaki

    IPC分类号： C07D215/56 ,  A61K31/47

    CPC分类号： C07D215/56

    摘要： The present quinoline derivatives and compositions having gonadotropin-releasing hormone antagonistic activity are useful as propylactics or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine or cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals, and as agents for promoting spawning in fish.

    摘要翻译： 本发明的喹诺酮衍生物和具有促性腺激素释放激素拮抗作用的组合物可用作预防或治疗若干激素依赖性疾病，例如性激素依赖性癌症（例如前列腺癌，子宫颈癌或宫颈癌，乳腺癌）的丙型或治疗剂 癌症，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前期综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）有效; 可用作男性或女性避孕药，作为排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用于调节畜牧业动物的发情周期，作为改善食用肉质量或促进动物生长的药剂，以及用于促进鱼类产卵的药剂。

    Nitrogen-containing heterocyclic compounds, their production and use
    4.
    发明授权
    Nitrogen-containing heterocyclic compounds, their production and use 失效
    含氮杂环化合物，其生产和使用

    公开(公告)号：US06962919B2

    公开(公告)日：2005-11-08

    申请号：US10042229

    申请日：2002-01-11

    申请人： Shuichi Furuya ,  Toshihiro Imaeda ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Toshihiro Imaeda ,  Satoshi Sasaki

    IPC分类号： A61K31/506 ,  A61P5/02 ,  A61P15/18 ,  C07D487/04 ,  C07D239/70 ,  A61K31/517 ,  A61P5/06

    CPC分类号： C07D487/04 ,  A61K31/506

    摘要： A compound of the formula: wherein one of A and D is N and the other is C, or both are N; B is N or C; m is 0-3; R1, R2 and R3 each is (i) H or (ii) a group bound via C, N, O or S; R4 is a group bound via C; R5 is H or a group bound via C or O; R6 is H or a group bound via C; R7 is a homo- or hetero-cyclic group which may be substituted; or a salt thereof possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful as a prophylactic or therapeutic agent for sex hormone-dependent diseases, and so forth.

    摘要翻译： 下式的化合物：其中A和D中的一个为N，另一个为C，或两者均为N; B是N或C; m为0-3; R 1，R 2和R 3各自为（i）H或（ii）通过C，N，O或S键合的基团 ; R 4是通过C键合的基团; R 5是H或通过C或O键合的基团; R 6是H或通过C键合的基团; R 7是可以被取代的同 - 或杂 - 环基团; 或其盐具有优异的促性腺激素释放激素拮抗活性，并且可用作性激素依赖性疾病的预防或治疗剂等。

    Nitrogen-containing heterocyclic compounds, their production and use
    5.
    发明授权
    Nitrogen-containing heterocyclic compounds, their production and use 有权
    含氮杂环化合物，其生产和使用

    公开(公告)号：US06413972B1

    公开(公告)日：2002-07-02

    申请号：US09711139

    申请日：2000-11-14

    申请人： Shuichi Furuya ,  Toshihiro Imaeda ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Toshihiro Imaeda ,  Satoshi Sasaki

    IPC分类号： C07D48704

    CPC分类号： C07D487/04 ,  A61K31/506

    摘要： A compound of the formula: wherein one of A and D is N and the other is C, or both are N; B is N or C; m is 0-3; R1, R2 and R3 each is (i) H or (ii) a group bound via C, N, O or S; R4 is a group bound via C; R5 is H or a group bound via C or O; R6 is H or a group bound via C; R7 is a homo- or hetero-cyclic group which may be substituted; or a salt thereof possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful as a prophylactic or therapeutic agent for sex hormone-dependent diseases, and so forth.

    摘要翻译： 下式的化合物：其中A和D中的一个为N，另一个为C，或两者均为N; B是N或C; m为0-3; R1，R2和R3各自为（i）H或（ii）通过C，N，O或S键合的基团; R4是通过C键合的基团; R5是H或通过C或O键合的基团; R6是H或通过C键合的基团; R7是可以被取代的同 - 或异环 - 基团; 或其盐具有优异的促性腺激素释放激素拮抗活性，并且可用作性激素依赖性疾病的预防或治疗剂等。

    Nitrogen-containing heterocyclic compounds, their production and use
    6.
    发明授权
    Nitrogen-containing heterocyclic compounds, their production and use 失效
    含氮杂环化合物，其生产和使用

    公开(公告)号：US06194419B1

    公开(公告)日：2001-02-27

    申请号：US09147616

    申请日：1999-02-02

    申请人： Shuichi Furuya ,  Toshihiro Imaeda ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Toshihiro Imaeda ,  Satoshi Sasaki

    IPC分类号： A61K31519

    CPC分类号： C07D487/04 ,  A61K31/506

    摘要： A compound of the formula: wherein one of A and D is N and the other is C, or both are N; B is N or C; m is 0-3; R1, R2 and R3 each is (i) H or (ii) a group bound via C, N, O or S; R4 is a group bound via C; R5 is H or a group bound via C or O; R6 is H or a group bound via C; R7 is a homo- or hetero-cyclic group which may be substituted; or a salt thereof possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful as a prophylactic or therapeutic agent for sex hormone-dependent diseases, and so forth.

    摘要翻译： 下式的化合物：其中A和D中的一个为N，另一个为C，或两者均为N; B是N或C; m为0-3; R1，R2和R3各自为（i）H或（ii）通过C，N，O或S键合的基团; R4是通过C键合的基团; R5是H或通过C或O键合的基团; R6是H或通过C键合的基团; R7是可以被取代的同 - 或异环 - 基团; 或其盐具有优异的促性腺激素释放激素拮抗活性，并且可用作性激素依赖性疾病的预防或治疗剂等。

    Filtration device
    7.
    发明授权
    Filtration device 有权
    过滤装置

    公开(公告)号：US09056267B2

    公开(公告)日：2015-06-16

    申请号：US14122682

    申请日：2012-05-30

    申请人： Tsutomu Sasaki ,  Satoshi Sasaki

    发明人： Tsutomu Sasaki ,  Satoshi Sasaki

    IPC分类号： B01D29/60 ,  B01D29/66 ,  B01D29/52 ,  C02F1/00

    CPC分类号： B01D29/668 ,  B01D29/52 ,  B01D29/60 ,  C02F1/001 ,  C02F2201/005 ,  C02F2201/007 ,  C02F2303/16

    摘要： A filtration device with filters that can be backwashed with purified water switches between water purification, first backwashing, and second backwashing modes, depending on a pivot position of a valve. During the first backwashing mode, while a tap water inlet is in communication with a second tap water passage port, first and second purified water passage ports are blocked from communication with a purified water outlet, so purified water from a second filter flows backward through a first filter and is discharged from a drain water outlet. During the second backwashing mode, while the tap water inlet is in communication with a first tap water passage port, first and second purified water passage ports are blocked from communication with the purified water outlet, so purified water from the first filter flows backward through the second filter and is discharged from the drain water outlet.

    摘要翻译： 具有过滤器的过滤装置，其可以根据阀的枢转位置在净水，第一反洗和第二反冲洗模式之间用净化水进行反冲洗。 在第一回洗模式期间，当自来水入口与第二自来水通道连通时，第一和第二净化水通道端口与净化水出口被阻止连通，所以来自第二过滤器的净化水通过 第一过滤器，并从排水出口排出。 在第二回洗模式期间，当自来水入口与第一自来水通道连通时，第一和第二净化水通道被阻止与净化水出口相通，所以来自第一过滤器的净化水向后流过 第二过滤器，并从排水出口排出。

    FILTRATION DEVICE
    8.
    发明申请
    FILTRATION DEVICE 有权
    过滤装置

    公开(公告)号：US20140110330A1

    公开(公告)日：2014-04-24

    申请号：US14122682

    申请日：2012-05-30

    申请人： Tsutomu Sasaki ,  Satoshi Sasaki

    发明人： Tsutomu Sasaki ,  Satoshi Sasaki

    IPC分类号： B01D29/66 ,  B01D29/60 ,  B01D29/52

    CPC分类号： B01D29/668 ,  B01D29/52 ,  B01D29/60 ,  C02F1/001 ,  C02F2201/005 ,  C02F2201/007 ,  C02F2303/16

    摘要： Provided is a filtration device with a plurality of filters that can be backwashed with purified water with a simple operation. The filtration device 1 switches between a water purification mode, a first backwashing mode, and a second backwashing mode, depending on a pivot position of a valve 6. During the first backwashing mode, while a tap water inlet 51 is in communication with a second tap water passage port 53, first and second purified water passage ports 54, 55 are blocked from communication with a purified water outlet 56, so that purified water from a second filter 3 flows backward through a first filter 2 and is discharged as drain water from a drain water outlet 57. During the second backwashing mode, while the tap water inlet 51 is in communication with a first tap water passage port 52, first and second purified water passage ports 53, 54 are blocked from communication with the purified water outlet 56, so that purified water from the first filter 2 flows backward through the second filter 3 and is discharged as drain water from the drain water outlet 57.

    摘要翻译： 提供了具有多个过滤器的过滤装置，其可以用简单的操作用净化水进行反冲洗。 过滤装置1根据阀6的枢转位置在水净化模式，第一回洗模式和第二回洗模式之间切换。在第一回洗模式期间，当自来水入口51与第二反洗 自来水通道端口53，第一和第二净化水通道端口54,55与净化水出口56阻止连通，使得来自第二过滤器3的净化水通过第一过滤器2向后流动，并作为排水从第 排水口57.在第二回洗模式期间，当自来水入口51与第一自来水通道端口52连通时，第一和第二净化水通道端口53,54被阻止与净化水出口56连通 ，使得来自第一过滤器2的净化水向后流过第二过滤器3，并且作为排水从排水出口57排出。