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公开(公告)号：US20060009449A1
公开(公告)日：2006-01-12
申请号：US11142738
申请日：2005-06-01
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Sussanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Sussanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/541 , A61K31/496 , A61K31/454 , C07D417/14 , C07D43/14
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：US20050282864A1
公开(公告)日：2005-12-22
申请号：US11157093
申请日：2005-06-20
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler , Jean Marc Plancher
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler , Jean Marc Plancher
IPC分类号： C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , A61K31/454 , C07D43/02
CPC分类号： C07D405/14 , C07D209/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to compounds of formula I: wherein X, R1, R2, R3, R4 and R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物：其中X，R 1，R 2，R 3，R 4， SUP和R 5如在说明书和权利要求书及其药学上可接受的盐中所定义，用于制备这些化合物和含有它们的药物组合物。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070265254A1
公开(公告)日：2007-11-15
申请号：US11821263
申请日：2007-06-22
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Jean-Marc Plancher , Susanne Raab , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/40 , A61K31/445 , A61K31/47 , A61K31/497 , A61K31/535 , A61K31/54 , A61P25/00 , C07D207/12 , C07D211/06 , C07D217/22 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D401/10 , C07D205/04 , C07D207/06 , C07D207/12 , C07D207/14 , C07D209/44 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D217/06 , C07D295/088 , C07D295/192
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, to the preparation of such compounds and pharmaceutical compositions containing them. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：US20060084679A1
公开(公告)日：2006-04-20
申请号：US11251509
申请日：2005-10-14
申请人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia McArthur , Cornelia Hertel , Matthias Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Rodriguez-Sarmiento , Franz Schuler
IPC分类号： A61K31/4709 , A61K31/47 , C07D401/02 , C07D215/38
CPC分类号： C07D401/14 , C07D215/48 , C07D401/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：US20060160855A1
公开(公告)日：2006-07-20
申请号：US11332955
申请日：2006-01-17
IPC分类号： A61K31/454 , C07D403/02 , A61K31/405
CPC分类号： C07D401/14 , C07D401/12
摘要： The present invention relates to compounds of formula I wherein R1, R2, R3, R4 and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3，R 4和R 4， m如说明书和权利要求书中所定义，以及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20070123526A1
公开(公告)日：2007-05-31
申请号：US11605005
申请日：2006-11-28
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Rosa Rodriguez Sarmiento , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Rosa Rodriguez Sarmiento , Sven Taylor
IPC分类号： A61K31/541 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20060122187A1
公开(公告)日：2006-06-08
申请号：US11290675
申请日：2005-11-30
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D213/74 , C07D213/82 , C07D213/83
摘要： The present invention relates to compounds of formula I wherein R1, R2 and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及其中R 1，R 2和A如说明书和权利要求书中所定义的式I化合物及其药学上可接受的盐以及药物 包含这些化合物的组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20060135528A1
公开(公告)日：2006-06-22
申请号：US11301052
申请日：2005-12-12
IPC分类号： A61K31/496 , C07D403/14
CPC分类号： C07D213/74 , C07D213/75 , C07D213/76
摘要： The present invention relates to compounds of formula I wherein R1, R2, X, Y, Z and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及其中R 1，R 2，X，Y，Z和m如说明书和权利要求书中所定义的式I化合物和药学上可接受的盐 以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07534788B2
公开(公告)日：2009-05-19
申请号：US12173888
申请日：2008-07-16
申请人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
发明人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , C07D405/06 , C07D409/06
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中X，A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07507736B2
公开(公告)日：2009-03-24
申请号：US12019682
申请日：2008-01-25
IPC分类号： A61K31/454 , A61K31/496 , C07D401/12 , C07D451/06
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D451/06
摘要： The present invention relates to compounds of formula I wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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