公开(公告)号：US20220402937A1

公开(公告)日：2022-12-22

申请号：US17814378

申请日：2022-07-22

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Andrea BAUER ,  Nandkumar Nivritti BHOGLE ,  Xiaoxia CHEN ,  Shahla JAMZAD ,  Robert Joseph PRYTKO ,  Kostas SARANTEAS ,  Michael Joseph SIZENSKY ,  Harold Scott WILKINSON ,  Haitao ZHANG

IPC: C07D495/04 ,  A61P25/18 ,  A61K9/20 ,  A61K45/06 ,  A61K31/381 ,  A61P25/00

Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.

公开(公告)号：US20210053983A1

公开(公告)日：2021-02-25

申请号：US17006101

申请日：2020-08-28

Applicant: Sunovion Pharmaceuticals Inc.

Inventor： Andrea BAUER ,  Nandkumar Nivritti BHOGLE ,  Xiaoxia CHEN ,  Shahla JAMZAD ,  Robert Joseph PRYTKO ,  Kostas SARANTEAS ,  Michael Joseph SIZENSKY ,  Harold Scott WILKINSON ,  Haitao ZHANG

IPC: C07D495/04 ,  A61P25/18 ,  A61K9/20 ,  A61K45/06 ,  A61K31/381 ,  A61P25/00

Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.