公开(公告)号：US09643938B2

公开(公告)日：2017-05-09

申请号：US15307386

申请日：2015-04-30

Applicant: Syngenta Participations AG

Inventor： Tomas Smejkal ,  Helmars Smits ,  Christian Lothschuetz ,  Miroslav Terinek

IPC: C07D261/04

CPC classification number: C07D261/04 ,  C07C259/06 ,  C07D261/12

Abstract: The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6cycloalkyl, aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes. Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.

公开(公告)号：US09815803B2

公开(公告)日：2017-11-14

申请号：US15477159

申请日：2017-04-03

Applicant: Syngenta Participations AG

Inventor： Tomas Smejkal ,  Helmars Smits ,  Christian Lothschuetz ,  Miroslav Terinek

IPC: C07D261/04 ,  C07C259/06

CPC classification number: C07D261/04 ,  C07C259/06 ,  C07D261/12

Abstract: The present invention relates to processes for the preparation of substituted cycloserine compounds of formula (I) wherein R1 is C1-C8alkyl, C1-C8haloalkyl, C3-C6 cycloalkyl, aryl or aryl substituted by one to five R11, or aryl-C1-C4alkylene or aryl-C1-C4alkylene substituted by one to five R11; and each R11 is independently C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, cyano or halogen; The invention also relates to intermediates produced by the processes.Compounds of formula (I) are useful intermediates for the production of compounds in the agricultural and pharmaceutical fields.

公开(公告)号：US09462807B2

公开(公告)日：2016-10-11

申请号：US14765212

申请日：2014-01-27

Applicant: Syngenta Participations AG

Inventor： Jeremy Robert Godwin ,  Alexander Mark Heming ,  Christian Lothschuetz ,  Peter Schneiter ,  Wolfgang Stutz

IPC: A01N25/00 ,  A01N43/653 ,  A01N43/64 ,  A61K31/41 ,  C07D405/06

CPC classification number: A01N43/653 ,  C07D405/06 ,  A01N25/32

Abstract: The present invention relates to a composition and its use in a method for safening the phytotoxic effect of difenoconazole on a plant or plant propagation material. More specifically the composition comprises difenoconazole characterised in that least 40% by weight of said difenoconazole is the 2R, 4S isomer depicted as formula (Ib): and wherein at least 95% by weight of the remaining difenoconazole is the 2S, 4S isomer depicted as formula (Id):

公开(公告)号：US09303054B2

公开(公告)日：2016-04-05

申请号：US14781980

申请日：2014-04-01

Applicant: Syngenta Participations AG

Inventor： Christian Lothschuetz ,  Alexandre Christian Saint-Dizier

IPC: C07F15/00 ,  B01J31/24

CPC classification number: C07F15/0053 ,  B01J31/2409 ,  B01J2231/643 ,  B01J2531/821

Abstract: The present invention relates to a process for the preparation of a compound of formula (I), wherein X is —CH2—, —CH2—CH2—, —CH2—CH2—CH2— or —CH2—CH2—CH2—CH2—; Y1 is —CH2—; —CH2—CH2— or —NH—; Y2 is NHR7 or SH; wherein R7 is hydrogen, C1-C4alkyl or phenyl; R-1 and R2, independently from each other, represent aliphatic or aromatic groups; R3 and R4, independently from each other, represent aliphatic or aromatic groups; R5 and R6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula II [RuCI2(R8)n]m (II), wherein n is 1 and m is >1 which represents a polymeric structure if R8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if R8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 1 12° C. to 165° C. with a compound of formula (III), wherein R5, R6, Y1 and Y2 are as defined under formula I, and a phosphane of formula IV R3R4P—X—PR1R2 (iv), wherein R1, R2, R3, R4 and X are as defined under formula I.

Abstract translation: 本发明涉及制备式（I）化合物的方法，其中X是-CH 2 - ， - CH 2 -CH 2 - ， - CH 2 -CH 2 - 或 - CH 2 -CH 2 -CH 2 - 。 Y1是-CH2-; -CH 2 -CH 2 - 或-NH-; Y2为NHR7或SH; 其中R 7是氢，C 1 -C 4烷基或苯基; R 1和R 2彼此独立地表示脂族或芳族基团; R 3和R 4彼此独立地表示脂族或芳族基团; R5和R6各自为氢或与它们所键合的碳原子一起表示苯环; 该方法包括使式II化合物[RuCl 2（R 8）n] m（II），其中n为1且m为> 1，其代表聚合物结构，如果R 8为含有在连接基中配位的两个烯烃或炔部分的分子 -2协调模式对金属; 如果R8是氮，氧或含硫分子，其中所述氮，氧或硫与金属配位，则n为4，m为1; 在与式（III）化合物的沸点为112℃至165℃的惰性溶剂的存在下，其中R 5，R 6，Y 1和Y 2如式I所定义， 式IV R3R4P-X-PR1R2（iv），其中R1，R2，R3，R4和X如式I所定义。