公开(公告)号：US11969703B2

公开(公告)日：2024-04-30

申请号：US17476621

申请日：2021-09-16

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Robert Toso ,  Richard Spanggord ,  Mei Tan ,  Van Taiariol ,  Yekaterina Lin

IPC: B01J19/00 ,  B01D29/01 ,  B01F27/13 ,  B01F35/45 ,  B01F35/71 ,  B01J8/00 ,  B01J19/18

CPC classification number: B01J19/18 ,  B01D29/01 ,  B01F27/13 ,  B01F35/451 ,  B01F35/712 ,  B01J8/006 ,  B01J19/0066 ,  B01J2208/00805 ,  B01J2208/00858

Abstract: An antibody-resin coupling apparatus quickly and efficiently activates resin beads and couples them to antibodies, while preventing breakdown and crosslinking of the beads, thereby improving downstream column purification processes, extending the usable life of the resin beads, and increasing molecule capture efficiency of the resultant resin-antibody complexes, to allow improved isolation and purification of factor VIII molecules or other drug compounds.