公开(公告)号：US11033550B2

公开(公告)日：2021-06-15

申请号：US16089533

申请日：2017-03-27

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Juran Kato ,  Hiroko Yamakawa ,  You Muraki ,  Gattu Mahanandeeshwar ,  Oruganty Satyalakshmi

IPC: A61K31/519 ,  A61P9/12

Abstract: An object of the present invention is to provide a medicament for preventing or treating pulmonary hypertension. The present invention provides a medicament for preventing or treating pulmonary hypertension, comprising a compound selected from the group consisting of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)-N-[1-ethyl-1-(4-methoxyphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-5-(2-fluorophenyl)-2,7,7-trimethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, and the salt thereof.