公开(公告)号：US20220175814A1

公开(公告)日：2022-06-09

申请号：US17594054

申请日：2020-04-03

申请人： TARGIMMUNE THERAPEUTICS AG

发明人： Derrick BROKA ,  David COLECCHIA ,  Lucia D'AMICO ,  Eric KITAS ,  Alexander LEVITZKI ,  Esteban POMBO-VILLAR ,  Alexei SHIR ,  Maya ZIGLER ,  Davor BAJIC ,  Anita JARZEBINSKA

IPC分类号： A61K31/713 ,  A61K47/60 ,  A61K47/64 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32 ,  C07K17/06

摘要： The present invention relates to a kit-of-parts comprising and a composition comprising a polyplex comprising a double stranded RNA (dsRNA) and a polymeric conjugate comprising a polyethyleneimine (PEI), one or more polyethylene glycol (PEG) moieties and one or more targeting moieties, and wherein each of said one or more targeting moieties is capable of binding to a cancer antigen; and at least one antibody, wherein said at least one antibody is capable of modulating an immune checkpoint protein. Further the invention relates to this composition or kit-of-parts for use in the treatment of cancer.