公开(公告)号：US11753655B2

公开(公告)日：2023-09-12

申请号：US17230484

申请日：2021-04-14

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Rachel M. Bailey ,  Steven J. Gray

IPC: C12N15/86 ,  C07K14/01 ,  A61P25/02 ,  A61K48/00 ,  C07K16/08

CPC classification number: C12N15/86 ,  A61K48/005 ,  A61P25/02 ,  C07K14/01 ,  C07K16/081

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.