公开(公告)号：US20180099002A1

公开(公告)日：2018-04-12

申请号：US15834052

申请日：2017-12-06

申请人： The Board of Regents of the University of Texas System ,  The Board of Trustees of the University of Illinois

发明人： Paul J. HERGENROTHER ,  David A. BOOTHMAN ,  Joseph S. BAIR ,  Lifen CAO ,  Jinming GAO ,  Xiumei HUANG ,  Xiuquan LUO ,  Xinpeng MA ,  Zachary R. MOORE ,  Elizabeth I. PARKINSON

IPC分类号： A61K31/706 ,  A61K31/4745 ,  A61K31/4738 ,  A61K31/131 ,  A61K45/06 ,  C12Q1/6886 ,  A61K31/353

摘要： The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

公开(公告)号：US20160030457A1

公开(公告)日：2016-02-04

申请号：US14783344

申请日：2014-04-08

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

发明人： Paul J. HERGENROTHER ,  David A. BOOTHMAN ,  Joseph S. BAIR ,  Lifen CAO ,  Jinming GAO ,  Xiumei HUANG ,  Xiuquan LUO ,  Xinpeng MA ,  Zachary R. MOORE ,  Elizabeth I. PARKINSON

IPC分类号： A61K31/706 ,  A61K31/4745 ,  A61K45/06 ,  A61K31/353 ,  A61K31/131

CPC分类号： A61K31/706 ,  A61K31/131 ,  A61K31/353 ,  A61K31/4738 ,  A61K31/4745 ,  A61K45/06 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  A61K2300/00

摘要： The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

摘要翻译： 本文所述的疗法可以选择性地对受试者中各种不同的癌细胞类型和癌症状况致命。 本文所述的联合治疗可用于治疗，治疗，控制或辅助治疗疾病，其中选择性致死性在化学治疗中是有益的，特别是在疾病伴随着NQO1水平升高的情况下。