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公开(公告)号：US20170210746A1
公开(公告)日：2017-07-27
申请号：US15324969
申请日：2015-07-14
发明人： Jennifer Carew , James G. Phillips
IPC分类号： C07D487/04 , A61K31/4709 , A61K45/06 , A61K31/382 , A61K31/519 , C07D409/12 , C07D335/16
CPC分类号： C07D487/04 , A61K31/382 , A61K31/4709 , A61K31/519 , A61K45/06 , C07D335/16 , C07D409/12 , Y02A50/411 , Y02A50/423 , A61K2300/00
摘要： Autophagy inhibitors useful for the treatment of cancer and other diseases are described. The autophagy inhibitors are a compound of formula: I wherein R1 is a group selected from lower alkyl, lower alkyl amide, lower alkyl ester, lower alkyl ketone, and lower alkyl ether; R2 and R3 are H or a group selected from cycloalkyl, lower alkyl, lower alkyl amide, lower alkyl ester, lower alkyl ketone, and lower alkyl ether; R4 is a heteroaryl group; and L is a —(CH2)n—X—(CH2)n— group, wherein n is 1, 2, 3, or 4, X is absent, O, S, or N—R5, wherein R5 is H or a lower alkyl group, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US09926326B2
公开(公告)日：2018-03-27
申请号：US15324969
申请日：2015-07-14
发明人： Jennifer Carew , James G. Phillips
IPC分类号： C07D487/04 , C07D409/12 , A61K31/4709 , C07D335/16 , A61K31/382 , A61K31/519 , A61K45/06
CPC分类号： C07D487/04 , A61K31/382 , A61K31/4709 , A61K31/519 , A61K45/06 , C07D335/16 , C07D409/12 , Y02A50/411 , Y02A50/423 , A61K2300/00
摘要： Autophagy inhibitors useful for the treatment of cancer and other diseases are described. The autophagy inhibitors are a compound of formula: I wherein R1 is a group selected from lower alkyl, lower alkyl amide, lower alkyl ester, lower alkyl ketone, and lower alkyl ether; R2 and R3 are H or a group selected from cycloalkyl, lower alkyl, lower alkyl amide, lower alkyl ester, lower alkyl ketone, and lower alkyl ether; R4 is a heteroaryl group; and L is a —(CH2)n—X—(CH2)n— group, wherein n is 1, 2, 3, or 4, X is absent, O, S, or N—R5, wherein R5 is H or a lower alkyl group, or a pharmaceutically acceptable salt thereof.
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