公开(公告)号：US20180305372A1

公开(公告)日：2018-10-25

申请号：US15694938

申请日：2017-09-04

申请人： THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY ,  GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang LAI ,  Xiaodong LIU ,  Bonian ZHONG ,  Shan ZHONG ,  Chuqin HUANG

IPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264

CPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264 ,  A61K2236/13 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02P20/544

摘要： The invention discloses a use of asarinin in preparation of medicines for treating various coughs. The asarinin is used for preparing medicines for treating various coughs separately or in combination with other medicines. The asarinin can be extracted by an SFE-CO2 method. The asarinin and usable drug carriers or excipients are made into various formulations. And the formulations are granules, tablets, capsules, soft capsules, pills, dripping pills, ointments, syrups, injection, oral liquid, tinctures, sustained-releasing drugs, controlled release drugs or targeting preparations.

公开(公告)号：US20170283428A1

公开(公告)日：2017-10-05

申请号：US15494538

申请日：2017-04-23

申请人： GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE

发明人： Kefang LAI ,  Xiaodong LIU ,  Bonian ZHONG ,  Shan ZHONG ,  Chuqin HUANG

IPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264

CPC分类号： C07D493/04 ,  A61K31/36 ,  A61K36/264 ,  A61K2236/13 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02P20/544

摘要： The invention discloses a method for extracting high-purity asarinin and use thereof. The method comprises: putting crude asarum powder in an SFE-CO2 device; under the conditions that an extraction kettle has a pressure of 30-40 Mpa and a temperature of 45-70° C., separating kettles I and II have a pressure of 5-10 Mpa, a temperature of 30-50° C. and the flow rate of CO2 is 35-60 L/h, extracting for 60-240 min to obtain total volatile oil of asarum; standing the total volatile oil of asarum for 24-72 h at a low temperature, and carrying out suction filtration under reduced pressure to obtain crude asarinin; and re-crystallizing the crude asarinin in absolute ethanol twice to obtain pure asarinin. It is found for the first time that asarinin has a good cough-relieving activity and thus can be used in preparing medicines for treating various types of coughs.