公开(公告)号：US20250002871A1

公开(公告)日：2025-01-02

申请号：US18708189

申请日：2022-11-07

Applicant: THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY

Inventor： Shiro TAKEKAWA ,  Hirotaka EBINA ,  Shinya OKAMURA ,  Akiho YOSHIDA

IPC: C12N7/00 ,  A61K9/00 ,  A61K39/00 ,  A61P31/14 ,  A61P37/04

Abstract: The purpose of the present invention is to provide a strain that is useful as a novel betacoronavirus vaccine. It is revealed that novel betacoronavirus, according to the present invention, having a prescribed substitution mutation relating to temperature sensitivity in combination with a prescribed deletion mutation relating to attenuation, is useful as a betacoronavirus vaccine strain having excellent attenuated characteristics.