公开(公告)号：US20180370910A1

公开(公告)日：2018-12-27

申请号：US16062253

申请日：2016-12-19

Applicant: THOMAS JEFFERSON UNIVERSITY ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Nir Ben-Tal ,  Roger S. Armen ,  Laurence C. Eisenlohr ,  Jitendra Belani ,  Michael Miller ,  Inbar Fish ,  Ori Kalid

IPC: C07C311/16 ,  A61P31/16 ,  C07C311/29

Abstract: An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating amantadine-resistant influenza A infections through administration of the same.

公开(公告)号：US11365174B2

公开(公告)日：2022-06-21

申请号：US16859121

申请日：2020-04-27

Applicant: Thomas Jefferson University ,  Ramot At Tel-Aviv University LTD.

Inventor： Nir Ben-Tal ,  Roger S. Armen ,  Laurence C. Eisenlohr ,  Jitendra Belani ,  Michael Miller ,  Inbar Fish ,  Ori Kalid

IPC: C07C311/16 ,  C07C311/29 ,  A61K31/63 ,  A61K31/18 ,  A61K31/352 ,  A61K31/167 ,  A61K31/04 ,  A61P31/16

Abstract: An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating amantadine-resistant influenza A infections through administration of the same.

公开(公告)号：US10676428B2

公开(公告)日：2020-06-09

申请号：US16062253

申请日：2016-12-19

Applicant: THOMAS JEFFERSON UNIVERSITY ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Nir Ben-Tal ,  Roger S. Armen ,  Laurence C. Eisenlohr ,  Jitendra Belani ,  Michael Miller ,  Inbar Fish ,  Ori Kalid

IPC: C07C311/16 ,  A61P31/16 ,  C07C311/29 ,  A61K31/63 ,  A61K31/18 ,  A61K31/352 ,  A61K31/167 ,  A61K31/04

Abstract: An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating amantadine-resistant influenza A infections through administration of the same.