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公开(公告)号：US20120303080A1
公开(公告)日：2012-11-29
申请号：US13493499
申请日：2012-06-11
申请人： Tamir BEN-DAVID , Omry BEN-EZRA , Ehud COHEN
发明人： Tamir BEN-DAVID , Omry BEN-EZRA , Ehud COHEN
CPC分类号： A61N1/3962 , A61N1/0556 , A61N1/36114 , A61N1/36117 , A61N1/3621 , A61N1/395
摘要： A method is provided, including identifying that a subject is at risk of suffering from atrial fibrillation (AF). Responsively to the identifying, a risk of an occurrence of an episode of the AF is reduced by coupling an electrode device to a site of a subject containing parasympathetic nervous tissue; driving, by a control unit, the electrode device to apply an electrical current to the site not responsively to any physiological parameters sensed by any device directly or indirectly coupled to the control unit; and configuring the current to stimulate autonomic nervous tissue in the site. Other embodiments are also described.
摘要翻译： 提供了一种方法，包括确定受试者处于心房颤动（AF）的风险。 响应于鉴定，通过将电极装置耦合到包含副交感神经组织的受试者的部位来降低发生AF发作的风险; 通过控制单元驱动电极装置，以不响应于直接或间接地耦合到控制单元的任何装置感测到的任何生理参数来施加电流到现场; 并配置电流以刺激现场的自主神经组织。 还描述了其它实施例。
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公开(公告)号：US20110137365A1
公开(公告)日：2011-06-09
申请号：US13022199
申请日：2011-02-07
申请人： Omry BEN-EZRA , Tamir BEN-DAVID , Ehud COHEN
发明人： Omry BEN-EZRA , Tamir BEN-DAVID , Ehud COHEN
CPC分类号： A61N1/36071 , A61N1/36114
摘要： Apparatus is provided including an electrode device and a control unit. The electrode device is configured to be coupled to a site of a subject selected from the group consisting of: a vagus nerve, an epicardial fat pad, a pulmonary vein, a carotid artery, a carotid sinus, a coronary sinus, a vena cava vein, a right ventricle, a right atrium, and a jugular vein. The control unit is configured to drive the electrode device to apply to the site a current in at least first and second bursts, the first burst including a plurality of pulses, and the second burst including at least one pulse, and set (a) a pulse repetition interval (PRI) of the first burst to be on average at least 20 ms, (b) an interburst interval between initiation of the first burst and initiation of the second burst to be less than 10 seconds, (c) an interburst gap between a conclusion of the first burst and the initiation of the second burst to have a duration greater than the average PRI, and (d) a burst duration of the first burst to be less than a percentage of the interburst interval between, the percentage being less than 67%. Other embodiments are also described.
摘要翻译： 提供了包括电极装置和控制单元的装置。 电极装置被配置为耦合到选自以下的对象的部位：迷走神经，心外膜脂肪垫，肺静脉，颈动脉，颈动脉窦，冠状窦，腔静脉 ，右心室，右心房和颈静脉。 所述控制单元被配置为驱动所述电极装置以至少第一和第二脉冲串向所述现场应用电流，所述第一脉冲串包括多个脉冲，所述第二脉冲串包括至少一个脉冲，并且设置（a） 脉冲重复间隔（PRI）平均至少为20ms，（b）第一脉冲串的起始与第二脉冲串的起始之间的间歇间隔小于10秒，（c）突发间隙 在第一突发的结论和第二突发的开始之间具有大于平均PRI的持续时间，以及（d）第一突发的突发持续时间小于突发间间隔的百分比，百分比为 小于67％。 还描述了其它实施例。
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