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公开(公告)号：US5616568A
公开(公告)日：1997-04-01
申请号：US158996
申请日：1993-11-30
申请人： Tara Pouyani , Glenn D. Prestwich
发明人： Tara Pouyani , Glenn D. Prestwich
IPC分类号： C08B37/08 , A61K31/715 , C07H1/00 , C07H5/04 , C07H5/06
CPC分类号： C08B37/0072 , Y10S514/944 , Y10S514/95 , Y10S514/964
摘要： Hyaluronate functionalized with dihydrazide is provided and may be cross-linked. A method for producing hyaluronate functionalized with dihydrazide includes mixing hyaluronate and dihydrazide in aqueous solution, then adding carbodiimide so that the hyaluronate and dihydrazide react to form functionalized hyaluronate.
摘要翻译： 提供用二酰肼官能化的透明质酸盐并且可以是交联的。 用二酰肼官能化的透明质酸盐的制备方法包括将透明质酸盐和二酰肼在水溶液中混合，然后加入碳二亚胺使得透明质酸盐和二酰肼反应形成官能化的透明质酸盐。
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公开(公告)号：US5652347A
公开(公告)日：1997-07-29
申请号：US484567
申请日：1995-06-07
申请人： Tara Pouyani , Glenn D. Prestwich
发明人： Tara Pouyani , Glenn D. Prestwich
CPC分类号： C08B37/0072 , Y10S514/944 , Y10S514/95 , Y10S514/964
摘要： Hyaluronate functionalized with dihydrazide is provided and may be cross-linked. A method for producing hyaluronate functionalized with dihydrazide includes mixing hyaluronate and dihydrazide in aqueous solution, then adding carbodiimide so that the hyaluronate and dihydrazide react to form functionalized hyaluronate.
摘要翻译： 提供用二酰肼官能化的透明质酸盐并且可以是交联的。 用二酰肼官能化的透明质酸盐的制备方法包括将透明质酸盐和二酰肼在水溶液中混合，然后加入碳二亚胺使得透明质酸盐和二酰肼反应形成官能化的透明质酸盐。
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3.发明申请COMPOUNDS WITH TRPV4 ACTIVITY, COMPOSITIONS AND ASSOCIATED METHODS THEREOF 审中-公开具有TRPV4活性的化合物，组合物及其相关方法公开(公告)号：US20130303539A1
公开(公告)日：2013-11-14
申请号：US13841790
申请日：2013-03-15
申请人： David Krizaj , Glenn D. Prestwich , Peter Barabas , Yong Xu , Daniel Ryskamp
发明人： David Krizaj , Glenn D. Prestwich , Peter Barabas , Yong Xu , Daniel Ryskamp
IPC分类号： C07D207/34 , A61K45/06 , A61K31/5377
CPC分类号： A61K31/5377 , A61K45/06 , C07D207/34 , C07D209/42 , C07D471/04
摘要： Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed.
摘要翻译： 提供了可用于治疗眼部疾病的化合物，组合物和方法。 特别地，公开了TRPV4的拮抗剂，它们的合成，其药物组合物和治疗眼部疾病如青光眼的方法。
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公开(公告)号：US20130172985A1
公开(公告)日：2013-07-04
申请号：US13522032
申请日：2011-01-13
IPC分类号： C07K14/435 , A61F2/06 , A61N5/06
CPC分类号： C07K14/435 , A61F2/06 , A61K41/0042 , A61L27/222 , A61L27/38 , A61L27/48 , A61L27/52 , A61N5/062 , C07K14/78 , C08H1/06 , C08J3/246 , C08J2305/08 , C08J2389/00 , C08K5/0025 , C08L89/06 , C08L2312/00 , C08L89/00
摘要： Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
摘要翻译： 本文描述的是修饰明胶或其药学上可接受的盐或酯，其包含共价键合到明胶上的至少一种可光化交联的基团。 修饰的明胶可用于生产最终可用于生产三维工程生物构建体的复合材料。 复合材料是改性明胶与至少一种可光化交联的大分子之间的聚合产物。 本文还描述了制备改性明胶的方法。
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5.发明授权Alkylated semi synthetic glycosaminoglycosan ethers, and methods for making and using thereof 有权烷基化半合成糖胺聚糖醚，及其制备和使用方法公开(公告)号：US08329673B2
公开(公告)日：2012-12-11
申请号：US13304292
申请日：2011-11-23
IPC分类号： A61K31/728 , A61K9/00 , C08B37/08 , A61P27/02 , A61P27/04
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein are alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated and alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including use for ocular or ophthalmic treatment.
摘要翻译： 本文所述的是烷基化和半合成的糖胺聚糖醚，在本文中称为SAGE。 还描述了硫酸化和烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括用于眼部或眼部治疗。
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公开(公告)号：US07981871B2
公开(公告)日：2011-07-19
申请号：US10581571
申请日：2004-12-06
申请人： Glenn D. Prestwich , Xiao Zheng Shu , Yanchun Liu
发明人： Glenn D. Prestwich , Xiao Zheng Shu , Yanchun Liu
IPC分类号： A01N43/04 , A01N25/00 , A61K31/715 , A61K31/727 , A61K47/00 , A61K9/14 , A61K9/50 , C07H5/04 , C07H5/06 , C08B37/00 , C08B37/10
CPC分类号： C08B37/0063 , A61L27/20 , C08B37/0069 , C08B37/0072 , C08B37/0075 , C08H1/06 , C08J3/075 , C08J2305/08 , C08L5/08 , C12N5/0068 , C12N2533/54 , C12N2533/80
摘要： Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.
摘要翻译： 本文描述的是已经通过引入至少一个酰肼反应性基团和/或氨氧基反应性基团来促进交联而被修饰的化合物，以及制备和使用它们用于无瘢痕伤口愈合的方法，用于递送 生物活性剂或活细胞，用于防止外科手术之后的粘连或用于骨和软骨修复。 大分子可以是寡核苷酸，碳酸，多肽，脂质，糖蛋白，糖脂，多糖，蛋白质或合成聚合物，优选糖胺聚糖如透明质酸。
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公开(公告)号：US20100330143A1
公开(公告)日：2010-12-30
申请号：US12764466
申请日：2010-04-21
IPC分类号： C07K14/78 , C08B37/00 , C08G63/91 , C08F120/10 , A61K31/728 , A61K38/39 , A61K31/74 , A61F2/00 , B05D5/00 , C12Q1/02 , C12N5/073
CPC分类号： C08B37/0072 , A61K31/728 , A61K31/74 , C08B15/10 , C08B37/003 , C08B37/0045 , C08B37/0069 , C08B37/0075 , C08B37/0084 , C08G63/91 , C08L2203/02 , C12N5/0068 , C12N2533/80 , C12N2537/10
摘要： Described herein are composites produced by reacting a first thiolated macromolecule with at least one compound having at least one thiol-reactive electrophilic functional group. The methods described herein permit the cross-linking of a variety of different thiolated macromolecules with one another. The composites described herein have a variety of biomedical and pharmaceutical applications, which are also described herein.
摘要翻译： 本文描述的是通过使第一硫醇化大分子与至少一种具有至少一个硫醇反应性亲电官能团的化合物反应制备的复合材料。 本文描述的方法允许各种不同硫醇化的大分子彼此交联。 本文描述的复合材料具有各种生物医学和药物应用，其也在本文中描述。
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公开(公告)号：US20110306581A1
公开(公告)日：2011-12-15
申请号：US13133126
申请日：2009-12-08
IPC分类号： A61K31/56 , A61K31/02 , A61K31/025 , A61P39/04 , A61P7/00 , A61P7/02 , A61P39/06 , A61K31/357 , C12N5/071
CPC分类号： A61K31/35 , A61K9/0026 , A61K9/107 , A61K31/00 , A61K31/56 , A61K47/08 , A61K47/34 , A61K47/36
摘要： Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered.
摘要翻译： 公开和描述了具有高稳定性和良好氧释放性的全氟化碳乳液。 这些全氟化碳乳剂通常用作人造氧载体。 全氟化碳乳液包括全氟化碳的分散相和乳液稳定剂以及连续相。 乳液稳定剂主要包括聚（环氧乙烷）嵌段共聚物。 这些稳定的全氟化碳乳液可用于灌注生物反应器或各种其它培养系统的液体和/或水凝胶相，以增强厚组织构建体中的细胞活力，或用作血液代用品，尽管也可考虑其他应用。
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9.发明申请公开(公告)号：US20100317616A1
公开(公告)日：2010-12-16
申请号：US12870763
申请日：2010-08-27
CPC分类号： A61K31/728 , A61K45/06 , C08B37/0072 , C08L5/08 , Y02A50/387
摘要： Described herein is the synthesis of alkylated and semi-synthetic glycosaminoglycosan ethers, referred to herein as “SAGEs.” The synthesis of sulfated alkylated SAGEs is also described. The compounds described herein are useful in a number of applications including wound healing, drug delivery, and the treatment of a number of inflammatory diseases and skin disorders.
摘要翻译： 本文描述的是合成烷基化和半合成的糖胺聚糖醚，本文称为“SAGE”。还描述了硫酸化烷基化SAGE的合成。 本文所述的化合物可用于许多应用，包括伤口愈合，药物递送以及治疗许多炎性疾病和皮肤病症。
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10.发明授权公开(公告)号：US07067269B2
公开(公告)日：2006-06-27
申请号：US09991933
申请日：2001-11-26
IPC分类号： G01N33/53
CPC分类号： G01N33/574 , G01N33/573 , G01N33/92
摘要： A lipid assay method, kit, and apparatus involving exposure of a protein, having a lipid recognition motif that interacts with a target lipid and a competing lipid, to a solution containing the competing lipid, and determining whether the target lipid is present in the solution. The target lipid has a stronger affinity to the lipid recognition motif than does the competing lipid. The lipid recognition motif is preferably a pleckstrin homology (PH) domain, with the target lipid being a phosphoinositide. The assay determines activity of a lipid kinase, the target lipid being a phosphorylation product of a reaction between the lipid kinase and a substrate lipid. The assay can be a cancer screening method for detection of cancer cells, where detection of certain levels of a PI(3,4,5)P3 target lipid is an indicator of a cancer cell.
摘要翻译： 一种脂质测定方法，试剂盒和装置，其涉及将具有与靶脂质和竞争性脂质相互作用的脂质识别基序的蛋白质暴露于含有竞争性脂质的溶液中，以及确定目标脂质是否存在于溶液中 。 目标脂质对脂质识别基序的亲和力高于竞争脂质。 脂质识别基序优选是pleckstrin同源性（PH）结构域，其中目标脂质是磷酸肌醇。 该测定法确定脂质激酶的活性，目标脂质是脂质激酶和底物脂质之间的反应的磷酸化产物。 该测定可以是用于检测癌细胞的癌症筛选方法，其中检测某些水平的PI（3,4,5）P 3/3靶标脂质是癌细胞的指标。
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