公开(公告)号：US20220098196A1

公开(公告)日：2022-03-31

申请号：US17428605

申请日：2020-01-31

Applicant: The Board of Regents of the University of Texas System

Inventor： Yonghao YU ,  Chuo CHEN ,  Shuai WANG ,  Lei HAN ,  Lin YOU

IPC: C07D471/06 ,  C07D401/14 ,  C07D417/14 ,  C07D487/06 ,  A61K45/06

Abstract: The disclosure provides PARP PROTAC molecules comprising a PARP inhibitor linked to an E3 ligase binder, and their use in treating diseases caused by aberrant PARP activation. Such PROTAC molecules produce selective degradation of one or a specific set of PARP proteins with limited effects on the protein level of other PARPs.