公开(公告)号：US20240218394A1

公开(公告)日：2024-07-04

申请号：US18504261

申请日：2023-11-08

申请人： The Trustees of the University of Pennsylvania

发明人： Jean Bennett ,  Junwei Sun ,  Kenneth Shindler ,  Devin McDougald ,  Ahmara Gibbons Ross

IPC分类号： C12N15/86 ,  A61K9/00 ,  A61K48/00 ,  A61P27/02

CPC分类号： C12N15/86 ,  A61K9/0048 ,  A61P27/02 ,  A61K48/00 ,  C12N2710/10043

摘要： Compositions and methods are provided for treating ocular neuropathy in a subject. In one aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding NRF2. In another aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding SIRT1. In desired embodiments, the subject is human, cat, dog, sheep, or non-human primate.

公开(公告)号：US11879133B2

公开(公告)日：2024-01-23

申请号：US16607834

申请日：2018-04-24

申请人： The Trustees of the University of Pennsylvania

发明人： Jean Bennett ,  Junwei Sun ,  Kenneth Shindler ,  Devin McDougald ,  Ahmara Gibbons Ross

IPC分类号： C12N15/86 ,  A61K9/00 ,  A61P27/02 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K9/0048 ,  A61P27/02 ,  A61K48/00 ,  C12N2710/10043

摘要： Compositions and methods are provided for treating ocular neuropathy in a subject. In one aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding NRF2. In another aspect, a recombinant adeno-associated viral vector is provided which includes a nucleic acid molecule comprising a sequence encoding SIRT1. In desired embodiments, the subject is human, cat, dog, sheep, or non-human primate.