公开(公告)号：US07674916B2

公开(公告)日：2010-03-09

申请号：US11688022

申请日：2007-03-19

申请人： Todd A. Werpy ,  John G. Frey, Jr. ,  James F. White ,  Johnathan E. Holladay ,  Alan H. Zacher

发明人： Todd A. Werpy ,  John G. Frey, Jr. ,  James F. White ,  Johnathan E. Holladay ,  Alan H. Zacher

IPC分类号： C07D207/267 ,  C07D213/63

CPC分类号： C07D207/404

摘要： The invention includes methods of processing an initial di-carbonyl compound by conversion to a cyclic compound. The cyclic compound is reacted with an alkylating agent to form a derivative having an alkylated ring nitrogen. The invention encompasses a method of producing an N-alkyl product. Ammonia content of a solution is adjusted to produce a ratio of ammonia to di-carboxylate compound of from about 1:1 to about 1.5:1. An alkylating agent is added and the initial compound is alkylated and cyclized. The invention includes methods of making N-methyl pyrrolidinone (NMP). Aqueous ammonia and succinate is introduced into a vessel and ammonia is adjusted to provide a ratio of ammonia to succinate of less than 2:1. A methylating agent is reacted with succinate at a temperature of from greater than 100° C. to about 400° C. to produce N-methyl succinimide which is purified and hydrogenated to form NMP.

摘要翻译： 本发明包括通过转化为环状化合物来处理初始二羰基化合物的方法。 环状化合物与烷基化剂反应形成具有烷基化环氮的衍生物。 本发明包括生产N-烷基产物的方法。 调节溶液的氨含量以产生约1：1至约1.5：1的氨与二羧酸酯化合物的比例。 加入烷基化剂并将该初始化合物烷基化并环化。 本发明包括制备N-甲基吡咯烷酮（NMP）的方法。 将氨水和琥珀酸钠引入容器中，并调节氨以提供小于2:1的氨与琥珀酸的比例。 甲基化剂与琥珀酸酯在大于100℃至约400℃的温度下反应，生成N-甲基琥珀酰亚胺，将其纯化并氢化形成NMP。