公开(公告)号：US20240325327A1

公开(公告)日：2024-10-03

申请号：US18599832

申请日：2024-03-08

申请人： Trustees of Dartmouth College

发明人： Ta Yuan CHANG ,  Catherine C.Y. CHANG ,  Adrianna DE LA TORRE ,  HaiBo LI ,  Thao N. HUYNH ,  Junghoon LEE

IPC分类号： A61K31/167 ,  A61K9/127 ,  A61K9/51 ,  A61K45/06 ,  A61P25/00

CPC分类号： A61K31/167 ,  A61K9/1271 ,  A61K9/5123 ,  A61K45/06 ,  A61P25/00

摘要： The present invention provides a method for preventing or treating neuroinflammation, amyloidopathy or tauopathy by inhibiting Acyl-CoA:Cholesterol Acyltransferase activity with a brain-permeable inhibitor encapsulated in a stealth liposome-based nanoparticle.