公开(公告)号：US20240241136A1

公开(公告)日：2024-07-18

申请号：US18537455

申请日：2023-12-12

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Ivan MARTINEZ-VALBUENA ,  Gabor G. KOVACS ,  Anthony E. LANG

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N2333/4728 ,  G01N2800/2835

Abstract: In an aspect, there is provided a method for differentiating movement disorders in a subject, comprising performing a seeding amplification assay for alpha-synuclein in a subject sample utilizing a specific buffer conditions, measuring the alpha-synuclein aggregation of the sample in the assay based on at least one of the following kinetic parameters: lag time, growth phase, T50, ThT max and AUC; and differentiating between Parkinson's Disease (PD) and Multiple System Atrophy (MSA) based on said sample kinetic parameters compared to control kinetic parameters, wherein control kinetic parameters for MSA show at least a two-fold difference from the control kinetic parameters for PD.