公开(公告)号：US20160045506A1

公开(公告)日：2016-02-18

申请号：US14776961

申请日：2014-03-14

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Steven A. GOLDMAN ,  Romane AUVERGNE

IPC: A61K31/519 ,  A61K31/4439 ,  A61K31/443

CPC classification number: A61K31/519 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4439 ,  A61K38/00 ,  C07K14/705 ,  G01N2333/726 ,  G01N2500/02 ,  G01N2800/7028

Abstract: The present invention relates to a method of treating glioma in a subject. The method comprises selecting a subject having a glioma, providing an inhibitor of binding between a PAR-1 receptor and a ligand of the PAR-1 receptor, and administering the inhibitor to the selected subject under conditions effective to treat the glioma and/or prevent spread of tumor cells. Methods for inhibiting proliferation of glioma cells and/or precursors thereof and a method of screening for compounds suitable for treating glioma in subjects are also disclosed.

Abstract translation: 本发明涉及治疗受试者中胶质瘤的方法。 该方法包括选择具有神经胶质瘤的受试者，提供PAR-1受体和PAR-1受体的配体之间的结合抑制剂，以及在有效治疗胶质瘤和/或预防的条件下将抑制剂施用于所选择的受试者 肿瘤细胞扩散。 还公开了抑制神经胶质瘤细胞和/或其前体的增殖的方法和筛选适合于治疗受试者中胶质瘤的化合物的方法。