公开(公告)号：US20210260002A1

公开(公告)日：2021-08-26

申请号：US17254008

申请日：2019-06-18

Applicant: UNIVERSITY OF ROCHESTER ,  UNIVERSITY OF COPENHAGEN

Inventor： Steven A. GOLDMAN ,  Zhengshan LIU ,  Mikhail OSIPOVITCH

IPC: A61K31/19 ,  A61K31/4184 ,  A61K31/5377 ,  C12N15/113 ,  A61P25/28

Abstract: The present disclosure is directed to methods of restoring glial cell K+ uptake in a subject. This method involves selecting a subject having impaired glial cell K+ uptake, and administering, to the selected subject, a RE1-Silencing Transcription factor (REST) inhibitor under conditions effective to restore glial cell K+ uptake. Subjects having impaired glial cell K+ uptake include those at risk of having or having a neuropsychiatric disease or disorder.

公开(公告)号：US20220025379A1

公开(公告)日：2022-01-27

申请号：US17413384

申请日：2019-12-11

Applicant: UNIVERSITY OF ROCHESTER

Inventor： Steven A. GOLDMAN ,  Zhengshan LIU

IPC: C12N15/113 ,  A61P25/18 ,  A61K31/713

Abstract: The present disclosure relates to methods of restoring K+ uptake by glial cells in a subject. These methods involve administering, to the subject, a SMAD4 inhibitor under conditions effective to restore K+ uptake by said glial cells. The present disclosure is also directed to methods of treating or inhibiting the onset of a neuropsychiatric disorder in a subject. These methods involve administering, to a subject in need thereof, a SMAD4 inhibitor under conditions effective to treat or inhibit the onset of the neuropsychiatric disorder in the subject.