公开(公告)号：US20170071925A1

公开(公告)日：2017-03-16

申请号：US15264704

申请日：2016-09-14

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ioulia Chatzistamou ,  Hippokratis Kiaris ,  Chrysovalantou Mihailidou

IPC: A61K31/4412 ,  A61K45/06

CPC classification number: A61K45/06 ,  A61K31/4418

Abstract: Modulation of glucose homeostasis by administration of ciclopirox (6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one) is described. Methods can be utilized in treatment of conditions that involve loss of glucose homeostasis, such as diabetes, and in one particular embodiment type II diabetes. Ciclopirox is shown to stimulate p21 expression by mechanisms that are likely p53-independent.

Abstract translation: 描述了通过施用环吡酮（6-环己基-1-羟基-4-甲基吡啶-2（1H） - 酮）来调节葡萄糖体内平衡。 方法可以用于治疗涉及葡萄糖体内平衡丧失的病症，例如糖尿病，以及在一个具体实施方案II型糖尿病中。 显示Ciclopirox通过可能与p53无关的机制刺激p21表达。

公开(公告)号：US10576151B2

公开(公告)日：2020-03-03

申请号：US15264704

申请日：2016-09-14

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ioulia Chatzistamou ,  Hippokratis Kiaris ,  Chrysovalantou Mihailidou

IPC: A61K31/4418 ,  A61K45/06

Abstract: Modulation of glucose homeostasis by administration of ciclopirox (6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one) is described. Methods can be utilized in treatment of conditions that involve loss of glucose homeostasis, such as diabetes, and in one particular embodiment type II diabetes. Ciclopirox is shown to stimulate p21 expression by mechanisms that are likely p53-independent.