公开(公告)号：US10202643B2

公开(公告)日：2019-02-12

申请号：US14354543

申请日：2012-10-31

Applicant: UNIVERSITY OF UTAH RESARCH FOUNDATION

Inventor： Orly Alter

IPC: C12Q1/6886 ,  C12Q1/6874 ,  C12N15/113 ,  C12Q1/6809 ,  G16H50/30 ,  G06F19/00

Abstract: Methods and genetic sequences are described for use in determining the diagnosis, subtype, prognosis, and disease course of high-grade gliomas, such as glioblastoma multiforme. One such method includes determining increased expression of at least one gene on a chromosome segment in cells of the glioma, the segment being 17:57,851,812-17:57,973,757; 7:127,892,509-7:127,947,649; 12:33,854-12:264,310; or 19:33,329,393-19:35,322,055; and estimating, based on the expression, a predicted length of survival, a probability of survival, or a predicted response to a therapy for the glioma.

公开(公告)号：US20140303029A1

公开(公告)日：2014-10-09

申请号：US14354543

申请日：2012-10-31

Applicant: UNIVERSITY OF UTAH RESARCH FOUNDATION

Inventor： Orly Alter

IPC: C12Q1/68

CPC classification number: C12Q1/6874 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Y201/01 ,  C12Y207/11001 ,  G06F19/00 ,  G16H50/30 ,  Y02A90/26 ,  C12Q2537/165

Abstract: Methods and genetic sequences are described for use in determining the diagnosis, subtype, prognosis, and disease course of high-grade gliomas, such as glioblastoma multiforme. One such method includes determining increased expression of at least one gene on a chromosome segment in cells of the glioma, the segment being 17:57,851,812-17:57,973,757; 7:127,892,509-7:127,947,649; 12:33,854-12:264,310; or 19:33,329,393-19:35,322,055; and estimating, based on the expression, a predicted length of survival, a probability of survival, or a predicted response to a therapy for the glioma.

Abstract translation: 描述了用于确定高级胶质瘤如多形性成胶质细胞瘤的诊断，亚型，预后和疾病过程的方法和基因序列。 一种这样的方法包括确定胶质瘤细胞中染色体片段上至少一个基因的表达增加，该片段为17：57,851,812-17：57,973,757; 7：127,892,509-7：127,947,649; 12：33,854-12：264,310; 或19：33,329,393-19：35,322,055; 并且基于表达来估计预测的存活时间长度，存活概率或对于胶质瘤治疗的预测响应。