公开(公告)号：US20210324010A1

公开(公告)日：2021-10-21

申请号：US17283708

申请日：2019-10-10

Applicant: University of Washington

Inventor： Caroline Tsao ,  Sijin Luozhong ,  Trevor Corrigan ,  Shaoyi Jiang ,  Erik Liu ,  Patrick McMullen

IPC: C07K14/00 ,  A61K47/64 ,  C07K14/535 ,  C07K14/56 ,  C07K14/435

Abstract: Charged polypeptides, their conjugates, and fusion proteins comprising such polypeptides are disclosed. Inclusion of such a polypeptide in a fusion protein increases the protein's properties such as stability and circulation half-life, which results in a better therapeutic efficacy compared to an active protein alone. Thus, a fusion protein or a conjugate of the disclosure can be useful in developing a protein or peptide drug, treating or preventing diseases, disorders, or conditions, or improving a subjects health or wellbeing.