专利检索 ap:("VIGONVITA LIFE SCIENCES CO., LTD." OR "SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES" OR "WUHAN INSTITUTE OF VIROLOGY, CHINESE ACADEMY OF SCIENCES") AND inv:"Tianwen HU" 第 1 页

1.

发明公开
SALT OF NUCLEOSIDE ANALOG, AND CRYSTAL FORM, PHARMACEUTICAL COMPOSITION AND USE THEREOF 审中-公开

公开(公告)号：US20230312584A1

公开(公告)日：2023-10-05

申请号：US18033673

申请日：2021-10-21

申请人： VIGONVITA LIFE SCIENCES CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , WUHAN INSTITUTE OF VIROLOGY, CHINESE ACADEMY OF SCIENCES

发明人： Jingshan SHEN , Yuanchao XIE , Leike ZHANG , Gengfu XIAO , Zhen WANG , Hualiang JIANG , Huaqiang XU , Tianwen HU , Guanghui TIAN

IPC分类号： C07D487/04

CPC分类号： C07D487/04 , C07B2200/13

摘要： A salt of nucleoside analog, and crystal form, pharmaceutical composition and use thereof. The salt of nucleoside analog has a structure shown in formula I, wherein X is hydrogen or deuterium; Y is an acid, n is 0.5 to 2, or n is 1. When X is hydrogen or deuterium, Y is hydrogen bromide, and n is 1, the salt of the nucleoside analog exists in the form of a crystal with crystal form I or crystal form A or exists in an amorphous form.