公开(公告)号：US10927126B2

公开(公告)日：2021-02-23

申请号：US16347457

申请日：2017-11-07

Applicant: Vanderbilt University

Inventor： Craig W. Lindsley ,  P. Jeffrey Conn ,  Darren W. Engers ,  Alison R. Gregro ,  Kayla Temple ,  Paul K. Spearing ,  Madeline F. Long ,  Julie L. Engers

IPC: C07D495/14 ,  A61K31/4375 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D519/00

Abstract: Disclosed herein are thieno[2,3-b:5,4-c′]dipyridin-8-amine and pyrido[4′,3′:4,5]thieno[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.

公开(公告)号：US20190330231A1

公开(公告)日：2019-10-31

申请号：US16347457

申请日：2017-11-07

Applicant: Vanderbilt University

Inventor： Craig W. Lindsley ,  P. Jeffrey Conn ,  Darren W. Engers ,  Alison R. Gregro ,  Kayla Temple ,  Paul K. Spearing ,  Madeline F. Long ,  Julie L. Engers

IPC: C07D495/14 ,  A61K45/06 ,  A61K31/5025 ,  A61K31/4375 ,  A61K31/5377 ,  A61K31/506 ,  C07D519/00

Abstract: Disclosed herein are thieno[2,3-b:5,4-c′]dipyridin-8-amine and pyrido[4′,3′:4,5]thieno[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.