公开(公告)号：US11607537B2

公开(公告)日：2023-03-21

申请号：US16210771

申请日：2018-12-05

申请人： Virginia Tech Intellectual Properties, Inc. ,  VoltMed, Inc.

发明人： Eduardo Latouche ,  Samuel Lesko ,  Lucy Epshteyn ,  Christopher B. Arena ,  John H. Rossmeisl, Jr. ,  Melvin Lorenzo ,  Rafael Davalos

IPC分类号： A61B18/08 ,  A61N1/05 ,  A61N1/32 ,  A61N1/37 ,  A61N1/36 ,  A61B18/14 ,  A61B18/00 ,  A61N1/08

摘要： This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.