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    Mannose-6-phosphonate compounds for the treatment of inflammatory diseases
    1.
    发明授权
    Mannose-6-phosphonate compounds for the treatment of inflammatory diseases 失效
    甘露糖-6-膦酸酯化合物，用于治疗炎性疾病

    公开(公告)号：US07648966B2

    公开(公告)日：2010-01-19

    申请号：US10557773

    申请日：2004-05-20

    申请人： William Butler Cowden ,  Gavin James Bartell ,  Bart Michael Eschler ,  Darren Ray March ,  Alan Robertson

    发明人： William Butler Cowden ,  Gavin James Bartell ,  Bart Michael Eschler ,  Darren Ray March ,  Alan Robertson

    IPC分类号： A61K31/70 ,  A61K31/7028

    CPC分类号： C07H19/04 ,  C07H11/04

    摘要： Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.

    摘要翻译： 公开了新型磷酸四氢吡喃化合物，其模拟甘露糖-6-磷酸，但对磷酸酶和甘露糖苷酶更具抗性，以及其药物组合物。 这些化合物和组合物抑制T淋巴细胞从血液迁移到组织或其他血管外部位。 通过抑制这种迁移，这些化合物可用于治疗至少部分通过这种T淋巴细胞迁移介导的疾病或病症。 这些疾病和病症包括类风湿性关节炎，多发性硬化症，急性播散性脑脊髓炎，牛皮癣，炎性肠病，T细胞介导的皮炎，基质角膜炎，葡萄膜炎，甲状腺炎，唾液炎和I型糖尿病。