公开(公告)号：US20240192198A1

公开(公告)日：2024-06-13

申请号：US18508058

申请日：2023-11-13

Applicant: Worcester Polytechnic Institute

Inventor： Christina M. Bailey-Hytholt ,  Daniel Zimmer

IPC: G01N33/50 ,  B33Y40/00 ,  B33Y70/00 ,  G01N33/531

CPC classification number: G01N33/5035 ,  B33Y70/00 ,  G01N33/5076 ,  G01N33/531 ,  B33Y40/00

Abstract: This disclosure relates generally to biomimetic proteoliposomes, a method of making and a method of using the same. In particular, this disclosure provides proteoliposomes comprising one or more phospholipid carrier and one or more protein embedded in the one or more phospholipid carrier, wherein the one or more phospholipid carrier comprises a phospholipid composition with similar proportions of phospholipids as a naturally occurring cell type and a phospholipid concentration of about 1-50 mM; and wherein the one or more protein comprises a protein composition with similar proportions of proteins as the naturally occurring cell type.