公开(公告)号：US20130102838A1

公开(公告)日：2013-04-25

申请号：US13693560

申请日：2012-12-04

Applicant: Worcester Polytechnic Institute

Inventor： Eric W. Overstrom ,  Elena Ibanez ,  Christine A. Lima

IPC: C12N15/877 ,  A61D19/04

CPC classification number: C12N15/8775 ,  A01K2217/05 ,  A01K2227/105 ,  A61D19/04 ,  C12N5/0609

Abstract: The invention pertains to the discovery that the presence of oocyte spindle associated factors in an enucleated oocyte improves oocyte quality and subsequently nuclear transfer. In particular, it was discovered that maintaining oocyte spindle factors in the oocyte after enucleation improves oocyte quality for use in nuclear transfer methodology.

Abstract translation: 本发明涉及以下发现：在去核卵母细胞中存在卵母细胞纺锤体相关因子改善了卵母细胞质量和随后的核转移。 特别是，发现在摘除卵母细胞后维持卵母细胞主轴因子改善了用于核转移方法的卵母细胞质量。