公开(公告)号：US20240086423A1

公开(公告)日：2024-03-14

申请号：US17898236

申请日：2022-08-29

Applicant: X Development LLC

Inventor： Lance Co Ting Keh ,  Ivan Grubisic ,  Ryan Poplin ,  Jon Deaton ,  Hayley Weir

IPC: G06F16/28 ,  G06N3/0455 ,  G06N3/08

CPC classification number: G06F16/285 ,  G06N3/0455 ,  G06N3/08

Abstract: Some techniques relate to projecting aptamer representations into an embedding space and clustering the representations. A cluster-specific binding metric can be defined for each cluster based on aptamer-specific binding metrics of aptamers associated with the cluster. A subset of the clusters can be selected based on the cluster-specific binding metrics. Identifications of aptamers assigned to the subset of clusters can then be output.

公开(公告)号：US20240087682A1

公开(公告)日：2024-03-14

申请号：US17932153

申请日：2022-09-14

Applicant: X Development LLC

Inventor： Jon Deaton ,  Hayley Weir ,  Ryan Poplin ,  Ivan Grubisic

IPC: G16B40/00 ,  G16B50/50

CPC classification number: G16B40/00 ,  G16B50/50

Abstract: A multi-dimensional latent space (defined by an Encoder model) corresponds to projections of sequences of aptamers. An architecture of the Encoder model, a hyperparameter of the Encoder model, or a characteristic of a training data set used to train the Encoder model was selected using an assessment of an encoding-efficiency of the Encoder model that is based on: a predicted extents to which representations in an embedding space are indicative of specific aptamer sequences to which a probability distribution of the embedding space differs from a probability distribution of a source space that represents individual base-pairs; generating projections in the latent space using representations of aptamers and the Encoder model; identifying one or more candidate aptamers for the particular target using the projections and the Decoder model; and outputting an identification of the one or more candidate aptamers.