公开(公告)号：US20140219979A1

公开(公告)日：2014-08-07

申请号：US14221887

申请日：2014-03-21

Applicant: Yeda Research and Development Co. Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Irun R. Cohen ,  Alexandra Zanin-Zhorov ,  Guy Tal ,  Francisco Quintana ,  Meirav Pisner ,  Ofer Lider

IPC: A61K38/17 ,  A61K35/14

CPC classification number: A61K38/1709 ,  A61K35/17 ,  A61K39/0008 ,  A61K2035/124 ,  A61K2039/5158 ,  A61K2039/53 ,  C12N5/0636 ,  C12N2501/07

Abstract: The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.

Abstract translation: 本发明提供了人类热休克蛋白60（HSP60）的肽p277-位置437-460在调节免疫应答和炎性疾病方面的新用途。 本发明进一步提供HSP60和p277在治疗或预防肝病中的新用途。 本发明公开了治疗，预防或改善T细胞介导的炎症和自身免疫性疾病（包括肝脏疾病）的症状的方法，其包括向有需要的受试者施用包含有效量的选自以下的分子的组合物： HSP60，p277，其片段，类似物，同源物及其衍生物，以及编码其的核酸。 还公开了用于治疗或预防T细胞介导的病症的T细胞疫苗接种方法。

公开(公告)号：US20150157588A1

公开(公告)日：2015-06-11

申请号：US14412838

申请日：2013-07-04

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Irun R. Cohen ,  Meir Shinitzky ,  Raanan Margalit ,  Michal Cohen-Sfady ,  Alexandra Zanin-Zhorov

IPC: A61K31/216

CPC classification number: A61K31/216

Abstract: The present invention relates to the compound amino-phenyl-acetic acid octadec-(Z)-9-enyl ester, an enantiomer thereof or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising it, for use in the treatment of tumors and metastases, and to methods for treating a tumor or metastases comprising administering said compound to a subject in need thereof. The present invention particularly relates to said compound when it is dissolved in an ethanol solution.

Abstract translation: 本发明涉及用于治疗肿瘤和转移的化合物氨基 - 苯基 - 乙酸十八 - （Z）-9-烯酯，其对映异构体或其药学上可接受的盐或包含它的药物组合物， 以及用于治疗肿瘤或转移的方法，包括向有需要的受试者施用所述化合物。 当本发明溶于乙醇溶液时，本发明特别涉及所述化合物。