公开(公告)号：US20140134196A1

公开(公告)日：2014-05-15

申请号：US14162482

申请日：2014-01-23

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Michal EISENBACH-SCHWARTZ ,  Ester YOLES ,  Oleg BUTOVSKY ,  Jonathan KIPNIS

IPC: A61K39/00

CPC classification number: A61K39/0007 ,  A61K39/00 ,  A61K39/0008 ,  A61K2039/5158

Abstract: Methods and compositions are provided for treatment of neurodegenerative diseases in which there is accumulation of misfolded and/or aggregated proteins, excluding prion diseases. In particular, the invention relates to treatment of the neurodegenerative diseases Huntington's disease (HD), Alzheimer's disease (AD) or Parkinson's disease (PD), by administration of an agent selected from the group consisting of (i) Copolymer 1, (ii) a Copolymer 1-related peptide, (iii) a Copolymer 1-related polypeptide, and (iv) T cells activated with (i), (ii) or (iii).

Abstract translation: 提供方法和组合物用于治疗除了朊病毒疾病之外存在错误折叠和/或聚集蛋白质积累的神经变性疾病。 特别地，本发明涉及治疗神经退行性疾病亨廷顿病（HD），阿尔茨海默病（AD）或帕金森病（PD）），通过施用选自（i）共聚物1，（ii） 共聚物1相关肽，（iii）共聚物1相关多肽，和（iv）用（i），（ii）或（iii）活化的T细胞。