公开(公告)号：US20140356350A1

公开(公告)日：2014-12-04

申请号：US14125588

申请日：2012-06-14

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Yosef Yarden ,  Pradeep Chaluvally-Raghavan

IPC: A61K39/395 ,  C12Q1/68 ,  A61K45/06 ,  G01N33/574 ,  A61K31/517 ,  A61K31/713

CPC classification number: A61K39/3955 ,  A61K31/506 ,  A61K31/517 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/39558 ,  A61K45/06 ,  C07K16/32 ,  C12N15/113 ,  C12N15/1135 ,  C12N15/1138 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57415 ,  A61K2300/00

Abstract: A method of treating a ductal carcinoma in situ (DCIS) lesion in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a first agent capable of down-regulating activity and/or expression of at least one component participating in a NOTCH pathway, and a second agent capable of down-regulating an activity and/or expression of HER2, thereby treating the DCIS lesion.

Abstract translation: 公开了在有需要的受试者中治疗原位导管原位癌（DCIS）病变的方法。 该方法包括向受试者施用治疗有效量的能够下调参与NOTCH途径的至少一种成分的活性和/或表达的第一种试剂，以及能够下调活性和/或 表达HER2，从而治疗DCIS损伤。