公开(公告)号：US20140178899A1

公开(公告)日：2014-06-26

申请号：US14105148

申请日：2013-12-12

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Adi Kimchi ,  Einat Zalckvar

IPC: G01N33/53

CPC classification number: G01N33/53 ,  C07K14/4703 ,  C07K14/4747 ,  C07K14/82 ,  C07K16/28 ,  C07K16/44 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/566 ,  G01N33/574 ,  G01N33/6893

Abstract: The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.

Abstract translation: 本发明涉及在Thr119位点磷酸化的人Beclin-1蛋白的特异性抗体及其应用。 特别地，这些抗体可用于诊断与自身受损有关的疾病，包括癌症和神经变性疾病。 本发明还涉及在位置119突变的人类Beclin-1，其具有磷酸模拟残基及其用于治疗癌症和神经变性疾病的用途。

公开(公告)号：US20140155330A1

公开(公告)日：2014-06-05

申请号：US14177840

申请日：2014-02-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Adi Kimchi ,  Assaf Rubinstein

IPC: C07K14/47 ,  G01N33/566 ,  G01N33/574

CPC classification number: C07K14/4747 ,  G01N33/566 ,  G01N33/5748

Abstract: Peptides, compositions and methods for modulating apoptosis, useful for treating diseases or disorders characterized by dysregulated apoptosis, such as cancer or neurodegenerative diseases. Screening methods for identifying agents that mediate apoptosis by regulating Atg12 binding to Bcl-2 family members.

Abstract translation: 用于调节凋亡的肽，组合物和方法，其可用于治疗以失调性细胞凋亡为特征的疾病或病症，例如癌症或神经变性疾病。 通过调节Atg12结合Bcl-2家族成员来鉴定介导凋亡的药剂的筛选方法。