公开(公告)号：US20210230597A1

公开(公告)日：2021-07-29

申请号：US17227483

申请日：2021-04-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Orna ISSLER

IPC: C12N15/113 ,  C12N15/11 ,  C12Q1/6883

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.

公开(公告)号：US20190055561A1

公开(公告)日：2019-02-21

申请号：US16180083

申请日：2018-11-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Orna ISSLER

IPC: C12N15/113 ,  C12Q1/6883 ,  C12N15/11

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.

公开(公告)号：US20200246372A1

公开(公告)日：2020-08-06

申请号：US16854978

申请日：2020-04-22

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

IPC: A61K31/7105 ,  A61P25/00 ,  A61K45/06 ,  C12N15/113

Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

公开(公告)号：US20180064748A1

公开(公告)日：2018-03-08

申请号：US15561990

申请日：2016-03-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

IPC: A61K31/7105 ,  C12N15/113

CPC classification number: A61K31/7105 ,  A61K45/06 ,  A61P25/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141

Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

公开(公告)号：US20180147233A1

公开(公告)日：2018-05-31

申请号：US15873998

申请日：2018-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI

IPC: A61K31/7105 ,  C12Q1/6883 ,  A61K31/713 ,  C12N15/113 ,  A61K48/00

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K48/0058 ,  C12N15/113 ,  C12N2310/141 ,  C12Q1/6883 ,  C12Q2600/178

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

公开(公告)号：US20160348101A1

公开(公告)日：2016-12-01

申请号：US15111539

申请日：2015-02-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Alon CHEN ,  Orna ISSLER

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/141 ,  C12N2320/30 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A method of treating a bipolar disorder in a subject in need thereof is disclosed. The method comprising administering to the subject sa therapeutically effective amount of a miR-135, a precursor thereof or a nucleic acid molecule encoding said miR-135 or said precursor thereof, thereby treating the bipolar disorder. Methods of diagnosing a mood disorder in a human subject and of monitoring treatment of an anti-depressant drug or a medicament for the treatment of a mood disorder are also disclosed.

Abstract translation: 公开了在有需要的受试者中治疗双相情感障碍的方法。 该方法包括向受试者施用治疗有效量的miR-135，其前体或编码所述miR-135或其前体的核酸分子，从而治疗双相情感障碍。 还公开了诊断人类受试者的情绪障碍和监测治疗抑郁药物或用于治疗情绪障碍的药物的方法。

公开(公告)号：US20240065988A1

公开(公告)日：2024-02-29

申请号：US18376875

申请日：2023-10-05

Applicant: Yeda Research and Development Co. Ltd. ,  Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Inventor： Alon CHEN ,  Juan Pablo LOPEZ

IPC: A61K31/135 ,  A61K31/216 ,  A61P25/24

CPC classification number: A61K31/135 ,  A61K31/216 ,  A61P25/24

Abstract: A method of treating a psychiatric disorder in a subject in need thereof is disclosed. The method comprising administering to the subject a therapeutically effective amount of an N-methyl-D-aspartate (NMDA) receptor antagonist and a therapeutically effective amount of a KCNQ channel activator. Pharmaceutical compositions comprising an NMDA receptor antagonist and a KCNQ channel activator are also disclosed.

公开(公告)号：US20240026357A1

公开(公告)日：2024-01-25

申请号：US18221914

申请日：2023-07-14

Applicant: Yeda Research and Development Co. Ltd. ,  miCure Therapeutics Ltd.

Inventor： Alon CHEN ,  Sharon MANASHIROV ,  Andres Pablo MONTEFELTRO

IPC: C12N15/113 ,  A61K47/55 ,  A61K47/54 ,  A61P25/24

CPC classification number: C12N15/113 ,  A61K47/55 ,  A61K47/548 ,  A61P25/24 ,  C12N2310/141

Abstract: A composition of matter comprising a synthetic miR-135 molecule comprising a nucleic acid sequence of a miR-135b as set forth in SEQ ID NO: 37, and a complementary strand as set forth in SEQ ID NO: 40 is disclosed. A conjugate comprising a composition of matter comprising a synthetic miR-135 molecule and a cell-targeting moiety is also disclosed.

公开(公告)号：US20210369761A1

公开(公告)日：2021-12-02

申请号：US17391125

申请日：2021-08-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Irit REICHENSTEIN ,  Alon CHEN

IPC: A61K31/7105 ,  C12N15/113 ,  A61K45/06 ,  A61P25/00

Abstract: A method of treating a subject having MND is provided. The method comprising administering to the subject a therapeutically effective amount of an agent selected from the group consisting of miR-218, miR-218*, precursor thereof and a polynucleotide sequence encoding miR-218 or miR-218* or precursor thereof, thereby treating the MND in the subject. A method of treating a subject having MND, the method comprising administering to the subject a therapeutically effective amount of an agent capable of downregulating an activity or expression of a gene product selected from the group consisting of KCND2, KCNH1, GABRB2, SLC6A1, SLC6A11, KCNA1, CACNB4, GRIA2, GRIK2, GABRG1 and GRIK3, is also provided.

公开(公告)号：US20220265696A1

公开(公告)日：2022-08-25

申请号：US17734199

申请日：2022-05-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon CHEN ,  Eran HORNSTEIN ,  Orna ISSLER ,  Sharon HARAMATI ,  Naama VOLK

IPC: A61K31/7105 ,  A61K31/713 ,  C12Q1/6883 ,  C12N15/113 ,  A61K48/00

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.