公开(公告)号：US20140155330A1

公开(公告)日：2014-06-05

申请号：US14177840

申请日：2014-02-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Adi Kimchi ,  Assaf Rubinstein

IPC: C07K14/47 ,  G01N33/566 ,  G01N33/574

CPC classification number: C07K14/4747 ,  G01N33/566 ,  G01N33/5748

Abstract: Peptides, compositions and methods for modulating apoptosis, useful for treating diseases or disorders characterized by dysregulated apoptosis, such as cancer or neurodegenerative diseases. Screening methods for identifying agents that mediate apoptosis by regulating Atg12 binding to Bcl-2 family members.

Abstract translation: 用于调节凋亡的肽，组合物和方法，其可用于治疗以失调性细胞凋亡为特征的疾病或病症，例如癌症或神经变性疾病。 通过调节Atg12结合Bcl-2家族成员来鉴定介导凋亡的药剂的筛选方法。