公开(公告)号：US20170362296A1

公开(公告)日：2017-12-21

申请号：US15696206

申请日：2017-09-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yechiel SHAI ,  Avner FINK ,  Eliran-Moshe REUVEN ,  Liraz GALIA

IPC: C07K14/705 ,  C07K7/08 ,  C07K4/00 ,  A61K38/10 ,  A61K38/04 ,  A61K38/03 ,  C07K14/00 ,  A61K38/16 ,  A61K38/00

CPC classification number: C07K14/705 ,  A61K38/00 ,  A61K38/03 ,  A61K38/04 ,  A61K38/10 ,  A61K38/16 ,  C07K4/00 ,  C07K7/08 ,  C07K14/00 ,  Y02A50/411

Abstract: Peptides are provided that are capable of inhibiting cell activation mediated by a Toll-like receptor (TLR) selected from TLR 1, 2, 4 or 6, said peptide comprising a sequence consisting of, or found within, the sequence of the transmembrane domain of a TLR selected from TLR 1, 2, 4 or 6 and optionally cytoplasmic and extracellular regions flanking the transmembrane domain. These peptides as well as pharmaceutical composition comprising them are useful for the treatment of TLR-mediated disease.