公开(公告)号：US20210162025A1

公开(公告)日：2021-06-03

申请号：US17166060

申请日：2021-02-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Eitan WONG ,  Ran AFIK

IPC: A61K38/48 ,  C12N9/64

Abstract: A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.

公开(公告)号：US20170304412A1

公开(公告)日：2017-10-26

申请号：US15636683

申请日：2017-06-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Eitan WONG ,  Ran AFIK

IPC: A61K38/48 ,  C12N9/64

CPC classification number: A61K38/4886 ,  C12N9/6489 ,  C12Y304/24086 ,  Y02A50/473

Abstract: A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.