公开(公告)号：US10017574B2

公开(公告)日：2018-07-10

申请号：US15147178

申请日：2016-05-05

Applicant: Yeda Research and Development Co. Ltd. ,  Victor Chang Cardiac Research Institute

Inventor： Eldad Tzahor ,  Gabriele Matteo D'Uva ,  Rachel Sarig ,  Alla Aharonov ,  Richard Paul Harvey ,  Kfir Baruch Umansky

IPC: A61K38/18 ,  A61K31/7115 ,  C07K16/28 ,  A61K39/395 ,  G01N33/50 ,  A61K38/17 ,  A61K9/00

CPC classification number: G01N33/5023 ,  A61K9/00 ,  A61K9/0019 ,  A61K9/0024 ,  A61K31/7115 ,  A61K38/1709 ,  A61K38/1825 ,  A61K38/1883 ,  G01N33/5061 ,  A61K2300/00

Abstract: A method of potentiating cardiac regeneration with neuregulin treatment in a subject in need thereof. The method comprising administering to the subject a therapeutic effective amount of an agent which upregulates activity or expression of ErbB-2, thereby potentiating cardiac regeneration with neuregulin treatment.

公开(公告)号：US20230173023A1

公开(公告)日：2023-06-08

申请号：US18106903

申请日：2023-02-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eldad Tzahor ,  Kfir Baruch Umansky ,  Rabea Hinkel ,  Christian Kupatt

IPC: A61K38/17 ,  A61P9/10

CPC classification number: A61K38/1709 ,  A61P9/10

Abstract: A method of treating an ischemic heart disease in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of Agrin in an anterograde intracoronary manner, thereby treating the ischemic heart disease in the subject.