公开(公告)号：US20170206308A1

公开(公告)日：2017-07-20

申请号：US15323994

申请日：2015-07-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Sarel FLEISHMAN ,  Gideon LAPIDOTH ,  Maria Gabriele PSZOLLA ,  Christoffer NORN

IPC: G06F19/16 ,  C40B30/02 ,  G06F19/18

Abstract: A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are based on a stochastic sampling of backbone conformations and amino acid conservation patterns observed in experimentally available protein structures having the common structural fold.