公开(公告)号：US20210338754A1

公开(公告)日：2021-11-04

申请号：US17335430

申请日：2021-06-01

申请人： Stephen H. THORNE

发明人： Stephen H. THORNE

IPC分类号： A61K35/768 ,  A61K45/06 ,  A61K31/7088 ,  C07K14/47 ,  A61P35/00

摘要： This disclosure relates to modified viruses, e.g., oncolytic vaccinia viruses, which have been modified to contain an exogenous nucleic acid that codes for a variant HMGB1 protein. It provides, at least in part, that vaccinia viruses modified to contain nucleic acid encoding variant HMGB1 and that express a variant HMGB1 or a fragment thereof can achieve a synergistic effect in combination with chemotherapy. Further, this disclosure provides for oncolytic vaccinia viruses and methods of using them in the treatment of various cancers.

公开(公告)号：US11065286B2

公开(公告)日：2021-07-20

申请号：US16335515

申请日：2017-09-21

申请人： Stephen H. Thorne

发明人： Stephen H. Thorne

IPC分类号： A61K35/768 ,  A61K45/06 ,  A61K31/7088 ,  A61P35/00 ,  C07K14/47

摘要： Provided herein are oncolytic vaccinia viruses which have been modified to contain an exogenous nucleic acid that codes for a variant HMGB1 protein. Such vaccinia viruses modified to contain nucleic acid encoding variant HMGB1 and that express a variant HMGB1 or a fragment thereof can achieve a synergistic effect in combination with chemotherapy. Methods of using oncolytic vaccinia viruses modified to contain an exogenous nucleic acid that codes for a variant HMGB1 protein, in the treatment of various cancers, are also provided.