摘要:
A penicillin derivative having an antibacterial activity similar to a penicillin antibiotic in a living body without affecting the intestinal bacterial colonies, a process for preparing the derivative and a pharmaceutical composition in a dosage unit form containing the derivative as an active ingredient are disclosed.
摘要:
The invention provides a hapten comprising a 6-[D-α-aminoacetamido] penicillin derivative crosslinked at the α-amino group with a substituted or unsubstituted phenyldicarbaldehyde. In addition, the invention provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of an intact β-lactam ring.
摘要:
A cephalosporin derivative having an antibacterial activity similar to a cephalosporin antibiotic in living bodies without affecting the intestinal bacterial colonies, a method for preparing the derivative and a pharmaceutical composition in a dosage unit form containing the derivative as an active ingredient are disclosed.
摘要:
Compound of formula I: 1 wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting null-lactamase enzymes, for enhancing the activity of null-lactam antibiotics, and for treating null-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.
摘要:
The invention provides a hapten comprising a 6-nullD-null-aminoacetamidonullpenicillin derivative crosslinked at the null-amino group with a substituted or unsubstituted phenyldicarbaldehyde. In addition, the invention provides an immunogen comprising the aforementioned hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of an intact null-lactam ring. The invention further provides a method and a kit for detecting, or determining the quantity of, null-lactam antibiotics, as well as, use of the aforementioned conjugate with the aforementioned antibodies for detecting, or determining the quantity of, null-lactam antibiotics. The present invention has broad specificity across the main first generation null-lactams and can be used to test milk and meat and the like for the presence of residual null-lactam antibiotics.
摘要:
A novel process for the preparation of an intermediate mixture which is useful in the production of penicillanic acid derivatives is described. The main component of the intermediate mixture is 2-((6-amino-3,3-dimethyl-7-oxo-4-thia-1azabicyclo(3,2,O)hept-2-yl)carbonyl) -1,2-benzisothiazol-3(2H)one-1,1-dioxide hydrochloride.