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公开(公告)号:US06444652B1
公开(公告)日:2002-09-03
申请号:US09459150
申请日:1999-12-10
IPC分类号: A61K3170
CPC分类号: C07H19/16 , A61K31/70 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , C07H19/06 , A61K2300/00
摘要: This invention is directed to a method for treating a host infected with hepatitis B comprising administering an effective amount of an anti-HBV biologically active 2′-deoxy-&bgr;-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof, wherein the 2′-deoxy-&bgr;-L-erythro-pentofuranonucleoside has the formula: wherein R is selected from the group consisting of H, straight chained, branched or cyclic alkyl, CO-alkyl, CO-aryl, CO-alkoxyalkyl, CO-aryloxyalkyl, CO-substituted aryl, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, amino acid residue, mono, di, or triphosphate, or a phosphate derivative; and BASE is a purine or pyrimidine base which may be optionally substituted. The 2′-deoxy-&bgr;-L-erythro-pentofuranonucleoside or a pharmaceutically acceptable salt or prodrug thereof may be administered either alone or in combination with another 2′-deoxy-&bgr;-L-erythro-pentofuranonucleoside or in combination with another anti-hepatitis B agent.
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公开(公告)号:US06407077B1
公开(公告)日:2002-06-18
申请号:US09435268
申请日:1999-11-05
IPC分类号: A61K317068
CPC分类号: A61K31/7068
摘要: Compounds and pharmaceutical compositions active against HIV are provided, as is a method for the treatment of HIV infection in humans and other host animals is provided comprising administering an effective amount of a &bgr;-L-(2′ or 3′-azido)-2′,3′-dideoxy-5-fluorocytosine of the formula wherein R is H, acyl, monophosphate, diphosphate, or triphosphate, or a stabilized phosphate derivative (to form a stabilized nucleotide prodrug), and R′ is H, acyl, or alkyl.
摘要翻译: 提供了对HIV有活性的化合物和药物组合物,如在人和其他宿主动物中治疗HIV感染的方法一样,提供有效量的β-L-(2'或3'-叠氮基)-2 ',3' - 二脱氧-5-氟胞嘧啶R是H,酰基,单磷酸,二磷酸或三磷酸,或稳定的磷酸酯衍生物(形成稳定的核苷酸前药),R'是H,酰基或烷基 。
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