公开(公告)号：US20090220189A1

公开(公告)日：2009-09-03

申请号：US12409003

申请日：2009-03-23

申请人： Peter Kiesel ,  Oliver Schmidt

发明人： Peter Kiesel ,  Oliver Schmidt

IPC分类号： G02B6/00

CPC分类号： G02F1/29 ,  G01J1/42 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/024 ,  G01J3/0256 ,  G01J3/26 ,  G01J3/2803 ,  G01J9/00 ,  G02B5/008 ,  G02B5/284 ,  G02B6/29317 ,  G02B6/4204 ,  G02B6/4298

摘要： Input light, such as from an optical sensor or stimulus-wavelength converter, includes one or more light or dark sub-bands. The input light is transmitted, such as through a transmissive layer or transmission component, to obtain effects due to transmission with lateral variation. A detector can, for example, obtain spectral information or other photon energy information about the sub-bands due to lateral variation. For each light or dark sub-band, a transmission component can, for example, provide a respective light or dark spot, and spot position can be used to obtain spectral information such as absolute wavelength or wavelength change. A photosensing component can sense or detect transmitted light or output photons, such as with a photosensor array or a position-sensitive detector. Circuitry can use photosensed quantities to obtain, e.g. a differential signal or information about time of wavelength change.

摘要翻译： 诸如来自光学传感器或刺激波长转换器的输入光包括一个或多个浅或暗的子带。 传输输入光，例如通过透射层或透射分量，以获得由于具有横向变化的透射而产生的影响。 检测器可以例如由于横向变化而获得关于子带的光谱信息或其他光子能量信息。 对于每个光或暗子带，透射分量可以例如提供相应的光斑或暗点，并且光斑位置可用于获得诸如绝对波长或波长变化的光谱信息。 感光组件可以感测或检测透射光或输出光子，例如用光电传感器阵列或位置敏感检测器。 电路可以使用光照量来获得，例如。 差分信号或有关波长变化时间的信息。

公开(公告)号：US07522811B2

公开(公告)日：2009-04-21

申请号：US11777661

申请日：2007-07-13

申请人： Oliver Schmidt ,  Michael Bassler ,  Peter Kiesel

发明人： Oliver Schmidt ,  Michael Bassler ,  Peter Kiesel

IPC分类号： G02B6/10

CPC分类号： G02B6/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/0259 ,  G01N21/0303 ,  G01N21/645 ,  G01N21/76 ,  G01N2021/0346 ,  G02B6/032

摘要： Complementary surface fabrication processes such as molding, casting, embossing, and so forth, are used to produce articles, structures, or components structured to operate as sandwich waveguides. Resulting complementary surface artifacts include, for example, optical quality surfaces on wall parts, other exposed artifacts that occur where a complementary solid surface contacts non-solid material during fabrication, and sub-surface artifacts such as integrally formed connections between wall parts and base parts. A body whose surface includes a waveguide's inward surfaces, outward surfaces, and light interface surfaces to receive incident light can be formed in a single step, leaving a partially bounded fluidic region that can then be covered to provide a channel that is bounded along a length yet open at its ends; other fluidic, electrical, and optical components can also be attached.

摘要翻译： 使用诸如模制，铸造，压花等的互补表面制造工艺来生产构造成作为夹层波导操作的制品，结构或部件。 所产生的互补表面伪影包括例如壁部件上的光学质量表面，在制造期间互补的固体表面与非固体材料接触时发生的其他暴露的假象以及诸如壁部件和基部之间的一体形成的连接的子表面伪影 。 可以在单个步骤中形成表面包括波导的内表面，外表面和光界面的表面的主体，留下部分界定的流体区域，然后可以将其覆盖以提供沿着长度限定的通道 尚未开放; 也可以连接其他流体，电和光学部件。

公开(公告)号：US07502123B2

公开(公告)日：2009-03-10

申请号：US11702249

申请日：2007-02-05

申请人： Oliver Schmidt ,  Peter Kiesel ,  Michael Bassler

发明人： Oliver Schmidt ,  Peter Kiesel ,  Michael Bassler

IPC分类号： G01B9/02 ,  G01J3/45

CPC分类号： G01N21/39 ,  G01N21/0303 ,  G01N21/253

摘要： Output light from an optical cavity includes, for each of a set of modes, an intensity function, and a mode's intensity function includes information, such as about an optical characteristic of an analyte or of a region. For example, the intensity function can include a peak, and its central energy, maximum intensity, contrast, or intermediate intensity width (e.g. FWHM) can indicate the optical characteristic. The output light can be photosensed, providing electrical signals that depend on the optical characteristic. Information about the analyte or region can then be obtained using the electrical signals. For example, the information can be about both refractive index and absorption of an analyte. Cavity-only absorption values, independent, for example, of absorption outside the cavity and of inhomogeneous illumination, can be obtained based on contrast or intermediate intensity width. For detection of glucose in bodily fluid, derivatives of absorption can be obtained.

摘要翻译： 来自光学腔的输出光对于一组模式中的每一个包括强度函数，并且模式的强度函数包括诸如关于分析物或区域的光学特性的信息。 例如，强度函数可以包括峰值，并且其中心能量，最大强度，对比度或中间强度宽度（例如，FWHM）可以指示光学特性。 输出光可以被光照，提供取决于光学特性的电信号。 然后可以使用电信号获得关于分析物或区域的信息。 例如，该信息可以关于分析物的折射率和吸收。 基于对比度或中等强度宽度，可以获得独立于例如空腔外的吸收和不均匀照射的仅腔吸收值。 为了检测体液中的葡萄糖，可以得到吸收的衍生物。

公开(公告)号：US07479625B2

公开(公告)日：2009-01-20

申请号：US12098584

申请日：2008-04-07

申请人： Peter Kiesel ,  Meng H. Lean ,  Oliver Schmidt ,  Armin R. Volkel ,  Noble M. Johnson

发明人： Peter Kiesel ,  Meng H. Lean ,  Oliver Schmidt ,  Armin R. Volkel ,  Noble M. Johnson

IPC分类号： G01J3/50

CPC分类号： G01N21/05 ,  G01N21/645 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/1734 ,  G01N2021/6421 ,  G01N2021/6482

摘要： A fluidic structure includes a channel and along the channel is a series of sensing components to obtain information about objects traveling within the channel, such as droplets or other objects carried by fluid. At least one sensing component includes a set of cells of a photosensor array. The set of cells photosense a range of photon energies that emanate from objects, and include a subset of cells that photosense within subranges. A processor can receive information about objects from the sensing components and use it to obtain spectral information. The processor can perform an initial analysis using information from one set of sensing components and, based on the results, control a fluidic device in the channel, such as a gate, to retain objects, such as for concentration and more detailed analysis by other sensing components, or to purge objects from the channel.

摘要翻译： 流体结构包括通道，并且沿着通道是一系列感测部件，以获得关于在通道内行进的物体的信息，例如由流体携带的液滴或其它物体。 至少一个感测组件包括一组光电传感器阵列的单元。 该组细胞照射从物体发出的一系列光子能量，并且包括在子范围内的光密度的子集。 处理器可以从感测组件接收关于对象的信息，并使用它来获得光谱信息。 处理器可以使用来自一组感测组件的信息来执行初始分析，并且基于该结果，控制通道（例如门）中的流体装置以保持对象，例如通过其他感测的浓度和更详细的分析 组件，或从通道清除对象。

公开(公告)号：US20080293872A1

公开(公告)日：2008-11-27

申请号：US12119138

申请日：2008-05-12

申请人： Helmut Loth ,  Carsten Friese ,  Johann Klein ,  Oliver Schmidt

发明人： Helmut Loth ,  Carsten Friese ,  Johann Klein ,  Oliver Schmidt

IPC分类号： C08K3/40

CPC分类号： C09J4/00 ,  C08F222/32 ,  C08K3/40 ,  C09D4/00 ,  C08L2666/28

摘要： The invention relates to chemically or physically curable compositions suitable as adhesives or sealants or coating materials, such compositions containing at least one binding agent selected from the group comprising crosslinkable or polymerizable monomers, prepolymers, or polymers, as well as at least one filler. The filler proportion is 0.2 to 70 wt % based on the total weight of the compositions, and at least a portion of the filler is made up of glass particles having a particle size from 100 nm to 20 μm, which have been obtained by comminuting foamed neutral or alkaline glass.

摘要翻译： 本发明涉及适用作粘合剂或密封剂或涂层材料的化学或物理可固化组合物，所述组合物含有至少一种选自包含可交联或可聚合单体，预聚物或聚合物的组合物以及至少一种填料。 填料比例为组合物总重量的0.2〜70重量％，填料的至少一部分由粒度为100〜20μm的玻璃粒子构成，通过粉碎发泡 中性或碱性玻璃。

公开(公告)号：US07456953B2

公开(公告)日：2008-11-25

申请号：US11777976

申请日：2007-07-13

申请人： Oliver Schmidt ,  Michael Bassler ,  Peter Kiesel ,  Patrick Y Maeda ,  Noble M Johnson

发明人： Oliver Schmidt ,  Michael Bassler ,  Peter Kiesel ,  Patrick Y Maeda ,  Noble M Johnson

IPC分类号： G01J3/30 ,  G01N21/64

CPC分类号： G02B6/10 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/33 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/64 ,  G01N21/65 ,  G01N2021/651 ,  G02B6/032 ,  G02B6/34

摘要： An improved method of analyzing target analytes in a sample is described. The method is based on creating an approximately homogeneous distribution of light in an anti-resonant guided optical waveguide to improve light-target interaction in a target-containing medium. The light-target interaction can be monitored by many different means to determine characteristics of the target analyte.

摘要翻译： 描述了一种分析样品中目标分析物的改进方法。 该方法基于在反谐振引导光波导中产生大致均匀的光分布，以改善含靶介质中的光 - 目标相互作用。 光靶相互作用可以通过许多不同的手段来监测，以确定目标分析物的特征。

公开(公告)号：US20080186503A1

公开(公告)日：2008-08-07

申请号：US11702250

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

IPC分类号： G01B9/02

CPC分类号： G01N21/031 ,  B01L3/5085 ,  G01J3/26 ,  G01N2021/391

摘要： An optical cavity, such as a laser or transmissive cavity, that can contain an analyte provides a different intensity-energy function with analyte present than when absent. The intensity-energy functions can, for example, include respective peaks that are different in at least one of central energy, amplitude, contrast, and full width half maximum (FWHM) (or other intermediate intensity width). Each intensity-energy function can include a set of modes in which the optical cavity provides output light. A laterally varying transmission component, such as a layered linearly varying filter, responds to the intensity-energy functions by providing different laterally varying energy distributions to a photosensing IC, and the distributions are also different, such as in position, size, or intensity. In response, the photosensing IC provides sensing results that are also different. The sensing results can be used to obtain information about the analyte, such as its refractive index or absorption coefficient.

摘要翻译： 可以包含分析物的光学腔，例如激光或透射腔提供与不存在时相比分析物存在的不同的强度能量函数。 强度能量函数可以例如包括在中心能量，幅度，对比度和全宽度半最大值（FWHM）（或其他中间强度宽度）中的至少一个中不同的各个峰值。 每个强度能量函数可以包括光学腔提供输出光的一组模式。 横向变化的传输部件，例如层状线性变化滤波器，通过向光敏IC提供不同的横向变化的能量分布来响应强度能量函数，并且分布也是不同的，例如位置，大小或强度。 作为响应，光敏IC提供也不同的感测结果。 感测结果可用于获得关于分析物的信息，例如其折射率或吸收系数。

公开(公告)号：US20080186488A1

公开(公告)日：2008-08-07

申请号：US11702328

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler

IPC分类号： G01N21/55 ,  G01N15/02 ,  G01N21/41

CPC分类号： G01N21/39 ,  G01N21/0303 ,  G01N2021/0346 ,  G01N2021/391

摘要： While objects travel through an optical cavity, the cavity provides output light that is affected by the objects, causing the output light to have a varying intensity function. The output light is photosensed to obtain sensing results that depend on the varying intensity function. The sensing results are used to distinguish at least one object, such as from its environment or from objects of other types. The objects can, for example, be particles or biological cells, and their optical characteristics, such as refractive index or absorption, can affect the output light, so that information about them is included in the output light. The output light can, for example, have a laterally varying intensity function with peaks whose features change due to the objects. The sensing results can also be used to track objects, together with other information, such as about the speed of a fluid that carries the objects through the cavity.

摘要翻译： 当物体通过光学腔时，空腔提供受物体影响的输出光，使得输出光具有变​​化的光强度功能。 输出光被光照以获得取决于变化强度函数的感测结果。 感测结果用于区分至少一个对象，例如与其环境或其他类型的对象。 物体可以是例如颗粒或生物细胞，并且它们的光学特性，例如折射率或吸收，可以影响输出光，使得关于它们的信息被包括在输出光中。 例如，输出光可以具有横向变化的强度函数，其峰值的特征由于对象而改变。 感测结果还可以用于跟踪物体以及其他信息，例如关于通过腔体传送物体的流体的速度。

公开(公告)号：US20080186483A1

公开(公告)日：2008-08-07

申请号：US11702329

申请日：2007-02-05

申请人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

发明人： Peter Kiesel ,  Oliver Schmidt ,  Michael Bassler ,  Richard H. Bruce ,  Noble M. Johnson

IPC分类号： G01N1/10

CPC分类号： G01N21/03 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14532 ,  A61B5/1459 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/31

摘要： An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.

摘要翻译： 可植入产品包括具有第一和第二部分的光学腔结构，每个部分可以作为光腔工作。 第一部分包括具有至少一个开口的容器，当产品植入体内时，体液可以通过该开口在容器的内部和外部之间转移。 第二部分包括封闭的容器并且包含参考流体。 可植入产品还可以包括光源组件和感光组件中的一个或两个。 可以根据第二部分输出指示灯的光线数量来调整第一部分输出光的照片数量。 两个部件可以使它们的光接口表面对准，使得它们都接收来自光源部件的输入光并且都向光敏部件提供输出光。

公开(公告)号：US20080183418A1

公开(公告)日：2008-07-31

申请号：US11698338

申请日：2007-01-26

申请人： Michael Bassler ,  Peter Kiesel ,  Oliver Schmidt

发明人： Michael Bassler ,  Peter Kiesel ,  Oliver Schmidt

IPC分类号： G06F15/00

CPC分类号： G01N21/6408 ,  G01N21/6458 ,  G01N2015/1075 ,  G01N2015/1486 ,  G06F19/12 ,  G06F2217/16 ,  G16H50/20

摘要： A method is provided for extracting the position of a particle, e.g., a moving or stationary particle that is excited or is emitting light. The method includes, among other steps, detecting and recording a signal based on, for example, the movement of the particle, a correlation step to eliminate noise and to create a transformed signal, a matching or fitting step to match the transformed signal to a fit function and an extracting or determining step to determine the position of the particle from the fit function. In one form, at least two particle positions are detected so that the distance between the subject particles can be determined.

摘要翻译： 提供了用于提取颗粒的位置的方法，例如被激发或正在发光的移动或静止的颗粒。 除了其他步骤之外，该方法包括基于例如粒子的移动来检测和记录信号，消除噪声并产生变换信号的相关步骤，匹配或拟合步骤，以将变换后的信号与 拟合函数和提取或确定步骤以从拟合函数确定粒子的位置。 在一种形式中，检测至少两个颗粒位置，使得可以确定主体颗粒之间的距离。