VIRAL GENOTYPING METHOD
    92.
    发明申请
    VIRAL GENOTYPING METHOD 审中-公开
    病毒基因组方法

    公开(公告)号:US20080154567A1

    公开(公告)日:2008-06-26

    申请号:US11959536

    申请日:2007-12-19

    IPC分类号: G06G7/58

    CPC分类号: G16B40/00 G16B20/00 G16B30/00

    摘要: The present invention relates to a method for developing algorithms that are capable of discriminating among different genotypes and subtypes of a virus of interest. The method includes aligning a set of viral nucleotide sequences having known genotypes and analyzing the aligned sequences to identify nucleotide positions at which the nucleotide is conserved within genotypes, but diversified across the different known genotypes. These positions, referred to herein as genotyping positions, are employed as predictive variables to compile a variable input table for analysis by a statistical classification algorithm. The variable input table also includes the nucleotide present at each genotyping position as a value and the genotype for each of the aligned sequences as a response variable. The algorithm analyzes the sequences of nucleotides at the genotyping positions across the aligned viral sequences, and uses the results of this analysis to specify parameters for each genotyping position that when combined across the genotyping positions will discriminate among the genotypes represented in the input sequences. The algorithm generated by this method is useful in a method of predicting the genotype of a viral isolate of interest, such as a virus present in a biological sample obtained from an individual.

    摘要翻译: 本发明涉及一种用于开发算法的方法,该算法能够区分感兴趣病毒的不同基因型和亚型。 该方法包括对齐具有已知基因型的一组病毒核苷酸序列并分析比对序列以鉴定核苷酸在基因型内保守的核苷酸位置,但跨不同已知基因型多样化。 这些位置,这里称为基因分型位置,被用作预测变量来编译用于通过统计分类算法进行分析的变量输入表。 可变输入表还包括存在于每个基因分型位置的核苷酸作为值,并将每个对齐序列的基因型作为响应变量。 该算法分析跨越比对的病毒序列的基因分型位置的核苷酸序列,并且使用该分析的结果来确定每个基因分型位置的参数,当跨基因分型位置组合时,将区分输入序列中表示的基因型。 通过该方法产生的算法可用于预测感兴趣的病毒分离物的基因型的方法,例如存在于从个体获得的生物样品中的病毒。

    Mycobacterial diagnostics
    93.
    发明申请
    Mycobacterial diagnostics 有权
    分枝杆菌诊断

    公开(公告)号:US20070042383A1

    公开(公告)日:2007-02-22

    申请号:US10934893

    申请日:2004-09-03

    IPC分类号: C12Q1/68

    CPC分类号: C12Q1/689 C12Q2600/16

    摘要: The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for methods of detecting M. paratuberculosis in a sample using nucleic acid molecules, polypeptides, and antibodies of the invention. The invention additionally provides methods of preventing a M. paratuberculosis infection in an animal.

    摘要翻译: 本发明提供了副结核分枝杆菌特有的核酸分子。 本发明还提供了由本发明的副结核分枝杆菌特异性核酸分子编码的多肽和对由副结核分枝杆菌特异性核酸分子编码的多肽具有特异性结合亲和力的抗体。 本发明还提供了使用本发明的核酸分子,多肽和抗体检测样品中副结核分枝杆菌的方法。 本发明另外提供了防止动物中副结核分枝杆菌感染的方法。

    Method and system for implementing instant communication of images through instant messaging tool
    94.
    发明申请
    Method and system for implementing instant communication of images through instant messaging tool 审中-公开
    通过即时通讯工具实现图像即时通讯的方法和系统

    公开(公告)号:US20060075054A1

    公开(公告)日:2006-04-06

    申请号:US11239681

    申请日:2005-09-29

    申请人: Qing Zhang Lu Han

    发明人: Qing Zhang Lu Han

    IPC分类号: G06F15/16

    CPC分类号: H04L51/04

    摘要: A method and a system thereof for implementing instant communication of images through instant messenger are provided in the present invention, image data processing module is added in the instant messenger, which is used to acquire image data and transit the acquired data into object data, then the object data are retransmitted to network side by instant messenger. The instant messenger inside receiving client extracts image data from the received information from the network side and displays contents of the information, namely displaying the image. By applying the present invention, instant communication and information interaction of images is implemented, practicability and interesting quality of instant messaging is further increased, new functions of instant messaging service are developed and value-added capability of instant messaging service is enhanced.

    摘要翻译: 在本发明中提供了一种用于通过即时消息传送实现图像即时通信的方法及其系统,图像数据处理模块被添加在即时消息中,用于获取图像数据并将所获取的数据传送到对象数据中,然后 对象数据通过即时消息传送到网络侧。 接收客户端内的即时信使从网络侧接收的信息中提取图像数据,并显示信息的内容,即显示图像。 通过应用本发明,实现了图像的即时通信和信息交互,进一步提高了即时消息的实用性和有趣的质量,开发了即时消息服务的新功能,并提高了即时消息服务的增值能力。

    Maximum auto-parking device
    95.
    发明授权
    Maximum auto-parking device 失效
    最大自动停车设备

    公开(公告)号:US5810539A

    公开(公告)日:1998-09-22

    申请号:US628527

    申请日:1996-04-05

    申请人: Ruyu Zhang Qing Zhang

    发明人: Ruyu Zhang Qing Zhang

    CPC分类号: E04H6/225

    摘要: A device for the efficient parking of vehicles is provided. The device includes: 1) a car-pan comprised of steel plate; 2) strengthening rods on the car-pan; 3) a parking space frame comprising a pair of steel C bars as its side beams and another pair of steel C bars as its end beams; 4) a number of (preferably two set) of free rollers with supports; 5) two pairs of driving rollers; 6) a parking power/control box affixed between the two side beams of the parking space; 7) chains connecting the driving rollers with the parking power/control box; 8) an elevator; 9) vertical rack-rails located at the two sides of the elevator; 10) an elevator power/control box affixed between the two side beams of the elevator; and 11) two pairs of chains connecting the driving rollers and the climbing gears of the elevator power/control box. The present device may further include 12) four cables with connectors, and 13) two balance weights between the vertical rack-rails.

    摘要翻译: 提供了用于车辆高效停车的装置。 该装置包括:1)由钢板组成的车盘; 2)加强车厢上的杆; 3)一个停车空间框架,包括一对钢C杆作为其侧梁,另一对钢C杆作为其端梁; 4)一些(优选两组)带支撑的自由辊; 5)两对驱动辊; 6)驻车位置/控制箱,固定在停车位的两侧梁之间; 7)将驱动辊与停车电源/控制箱连接的链条; 8)电梯; 9)位于电梯两侧的垂直机架导轨; 10)电梯功率/控制箱,固定在电梯的两侧梁之间; 和11)连接电梯功率/控制箱的驱动辊和爬升齿轮的两对链条。 本装置还可以包括12)具有连接器的四条电缆,以及13)在垂直机架轨道之间的两个平衡重。

    Oral Irrigator
    97.
    发明申请
    Oral Irrigator 审中-公开

    公开(公告)号:US20190201175A1

    公开(公告)日:2019-07-04

    申请号:US15856101

    申请日:2017-12-28

    IPC分类号: A61C17/02 A61C1/00

    CPC分类号: A61C17/032 A61C1/0092

    摘要: An oral irrigator contains: a body, a water tank and a detachable jet tip which are both in connection with the body, a power device and a control device Which are both accommodated in the body. The power device is configured to deliver water from the water tank to the detachable jet tip. The power device includes a first outlet defined thereon and configured to discharge the water, a delivery tube connecting with the first outlet, and a first seal element configured to stop water flowing into the body from the power device so that the water discharges out of the first outlet.

    Method for sensing connection port, connection port sensing apparatus and computer system using the same
    98.
    发明授权
    Method for sensing connection port, connection port sensing apparatus and computer system using the same 有权
    用于感测连接端口,连接端口感测装置和使用其的计算机系统的方法

    公开(公告)号:US08907805B2

    公开(公告)日:2014-12-09

    申请号:US13556376

    申请日:2012-07-24

    申请人: Qing Zhang

    发明人: Qing Zhang

    IPC分类号: G08B21/00

    摘要: The present disclosure relates to a method for sensing a connection port and a connection port sensing apparatus thereof. The method includes the steps of: providing a sensing device nearing a connection port; providing a lighting device nearing the connection port; lighting the lighting device by a connection port sensing apparatus when the sensing device detects that an object is nearing the connection port, concurrently, displaying a message through the operating system to notify the user of the corresponding information about the connection port.

    摘要翻译: 本公开涉及用于感测连接端口及其连接端口感测装置的方法。 该方法包括以下步骤:提供靠近连接端口的感测装置; 提供靠近连接端口的照明装置; 当感测装置检测到对象正在接近连接端口时,通过连接端口感测装置点亮照明装置,同时通过操作系统显示消息以向用户通知关于连接端口的相应信息。

    COMPOUNDS AND METHODS OF PROPHYLAXIS AND TREATMENT REGARDING NICOTINIC RECEPTOR ANTAGONISTS
    99.
    发明申请
    COMPOUNDS AND METHODS OF PROPHYLAXIS AND TREATMENT REGARDING NICOTINIC RECEPTOR ANTAGONISTS 有权
    关于NICOTINIC受体拮抗剂的预防和治疗的化合物和方法

    公开(公告)号:US20140205595A1

    公开(公告)日:2014-07-24

    申请号:US14127699

    申请日:2012-06-22

    摘要: It is an object of the present invention that the novel nicotinic receptor antagonists disclosed herein may be used in a broad array of clinical or medicinal facets. For example, it is a contemplated use of the present invention that the novel nicotinic receptor antagonists be used to inhibit the growth cycle of non-small cell lung cancer cells. Without being bound by theory, it is an object of the present invention that the nicotinic receptor antagonists disclosed herein are believed to possess reversible binding properties. Moreover, the compounds of the present invention are selective for 0.7 nAChR. For example, the compounds of the present invention are not believed to bind to 0.4 (32 nAChR neuromuscular receptors. It is also contemplated that the nicotinic receptor antagonists of the present invention will be used as a counter measure to treat exposure, or potential exposure, to a wide array of potential neurotoxins.

    摘要翻译: 本发明的目的是本文公开的新型烟碱受体拮抗剂可用于广泛的临床或药用方面。 例如,本发明的预期用途是使用新颖的烟碱受体拮抗剂来抑制非小细胞肺癌细胞的生长周期。 不受理论的约束,本发明的目的是认为本文公开的烟碱型受体拮抗剂具有可逆结合性质。 此外,本发明的化合物对于0.7nAChR是选择性的。 例如,本发明的化合物不被认为与0.4(32 nAChR)神经肌肉受体结合,也可以考虑将本发明的烟碱受体拮抗剂用作治疗暴露或潜在暴露的对策, 到各种潜在的神经毒素。

    Selection of polishing parameters to generate removal profile
    100.
    发明授权
    Selection of polishing parameters to generate removal profile 有权
    选择抛光参数以产生去除曲线

    公开(公告)号:US08774958B2

    公开(公告)日:2014-07-08

    申请号:US13098257

    申请日:2011-04-29

    IPC分类号: G06F19/00 B24B49/00

    摘要: Values are selected for a plurality of controllable parameters of a chemical mechanical polishing system that includes a carrier head with a plurality of zones to apply independently controllable pressures on a substrate. Data is stored relating variation in removal profile on a front surface of the substrate to variation in the controllable parameters, the data including removal at a plurality of positions on the front surface of the substrate, there being a greater number of positions than chambers. A value is determined for each parameter of the plurality of controllable parameters to minimize a difference between a target removal profile and an expected removal profile calculated from the data relating variation in removal profile on a front surface of the substrate to variation in the parameters. The value for each parameter of the plurality of controllable parameters is stored.

    摘要翻译: 为化学机械抛光系统的多个可控参数选择值,其包括具有多个区域的载体头,以在基底上施加独立的可控压力。 存储数据存储在基板的前表面上的去除轮廓的变化,以改变可控参数,包括在基板的前表面上的多个位置处的去除的数据,存在比腔更多的位置数量。 为多个可控参数的每个参数确定一个值,以最小化目标去除曲线与根据数据相关的预期去除曲线之间的差异,该数据与基板的前表面上的去除曲线的变化相关,参数的变化。 存储多个可控参数的每个参数的值。