公开(公告)号：US20070042990A1

公开(公告)日：2007-02-22

申请号：US11005471

申请日：2004-12-06

申请人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

发明人： Gilles Gosselin ,  Richard Storer ,  Paola LaColla ,  Jean-Pierre Sommadossi

IPC分类号： A61K38/16 ,  C07H19/16 ,  A61K31/7076 ,  A61K38/14

CPC分类号： C07K9/003 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/00 ,  A61K45/06 ,  C07H19/06 ,  C07H19/067 ,  A61K2300/00

摘要： 2′ and 3′-Prodrugs of 1′, 2′, 3′ or 4′-branched β-D or β-L nucleosides, or their pharmaceutically acceptable salts and derivatives are described, which are useful in the prevention and treatment of Flaviviridae infections and other related conditions. These modified nucleosides provide superior results against flaviviruses and pestiviruses, including hepatitis C virus and viruses generally that replicate through an RNA dependent RNA reverse transcriptase. Compounds, compositions, methods and uses are provided for the treatment of Flaviviridae infection, including HCV infection, that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.